Parameters of oxidative stress and echocardiographic indexes in patients on dialysis therapy

Figures & data

TABLE 1.  Demographic clinical and biochemical properties of patients and control group

Parameter	Patients group (n = 71)	Control group (n = 30)	P	CAPD (n = 39)	HD (n = 32)	p
Age (years)	40.9 ± 14.0	38.0 ± 10.5	0.389	38.9 ± 13.0	43.4 ± 15.0	0.183
Sex (M/F)	34/37	14/16	0.983	17/22	17/15	0.424
BMI (kg/m^2)	21.9 ± 4.3	24.3 ± 3.7	0.025	22.3 ± 3.8	21.4 ± 4.9	0.386
SBP (mmHg)	136.6 ± 28.2	116.6 ± 12.3	0.002	136.6 ± 32.1	136.5 ± 23.0	0.988
DBP (mmHg)	83.9 ± 13.6	77.1 ± 9.0	0.035	85.6 ± 13.7	81.8 ± 13.5	0.251
Glucose (mg/dL)	104.3 ± 49.9	93.1 ± 11.8	0.314	118.6 ± 62.7	87.7 ± 17.1	0.010
Na (mEq/L)	139.5 ± 3.5	139.8 ± 2.2	0.791	139.2 ± 3.6	139.9 ± 3.4	0.419
K (mEq/L)	4.8 ± 1.0	4.1 ± 0.2	0.003	4.5 ± 0.9	5.1 ± 1.0	0.014
Ca (mg/dL)	9.3 ± 1.2	9.3 ± 0.3	0.901	9.5 ± 1.2	9.1 ± 1.1	0.108
P (mg/dL)	5.9 ± 2.0	3.7 ± 0.5	<0.001	5.2 ± 1.6	6.7 ± 2.0	0.002
Ca  ×  P (mg^2/dL^2)	55.2 ± 19.2	34.9 ± 4.9	<0.001	50.9 ± 20.1	60.5 ± 16.9	0.036
iPTH (pg/mL)	382.6 ± 386.9	49.5 ± 19.1	<0.001	383.9 ± 75.5	380.9 ± 45.0	0.974
Hemoglobin (g/dL)	10.4 ± 1.7	14.4 ± 1.2	<0.001	10.6 ± 1.9	10.2 ± 1.4	0.387
Ferritin (ng/mL)	1157.2 ± 1641.7	100.5 ± 104.4	0.004	999.9 ± 630.8	1349.0 ± 2351.4	0.377
Albumin (g/dL)	3.3 ± 0.5	4.3 ± 0.2	<0.001	3.1 ± 0.6	3.5 ± 0.5	0.009
CRP (mg/dL)	13.5 ± 29.4	3.4 ± 0.4	0.119	14.6 ± 5.2	12.2 ± 4.4	0.735
Fibrinogen (mg/dL)	516.7 ± 166.7	250.9 ± 52.4	<0.001	587.0 ± 174.9	442.0 ± 121.6	0.0001
T.Cholesterol (mg/dL)	185.6 ± 56.6	171.7 ± 36.7	0.292	200.7 ± 61.1	167.2 ± 44.4	0.012
Triglyceride (mg/dL)	185.8 ± 139.4	140.1 ± 97.1	0.164	186.1 ± 27.1	185.5 ± 16.4	0.986
LDL-C (mg/dL)	111.9 ± 38.1	97.9 ± 29.2	0.126	121.3 ± 37.5	100.3 ± 36.3	0.020
HDL-C (mg/dL)	38.6 ± 12.0	45.9 ± 10.4	0.014	43.9 ± 12.7	32.1 ± 6.9	<0.001

Note: BMI, body mass index; SBP, systolic blood pressure; DBP, diastolic blood pressure.

TABLE 2.  Parameters of pro-oxidant and antioxidants between patients and controls

Parameters	Patient group (n = 71)	Control group (n = 30)	p
MDA (μmol/L)	5.9 ± 2.4	5.1 ± 1.8	0.202
GSH-px (U/dL)	65.5 ± 3.4	71.0 ± 28.6	0.456
SOD (U/gHb)	1391.6 ± 252.9	1730.4 ± 228.4	<0.001

FIGURE 1.  Comparison of SOD levels between dialysis patients and control group.

TABLE 3.  Oxidative stress and echocardiographic data

Parametrial	HD (n = 32)	CAPD (n = 39)	p
MDA	6.2 ± 2.8	5.5 ± 1.9	0.224
GSH-px	63.7 ± 8.0	68.0 ± 41.8	0.425
SOD	1589.7 ± 274.0	1366.8 ± 234.8	0.039
EF	63.1 ± 6.5	62.0 ± 3.3	0.373
IVSd	1.18 ± 0.18	1.20 ± 0.22	0.718
LVPWd	1.33 ± 0.20	1.18 ± 0.22	0.378
LAd	3.3 ± 0.5	3.4 ± 0.5	0.492

FIGURE 2.  Comparison of malondialdehyde levels between HD, CAPD, and control groups.

FIGURE 3.  Comparison of glutathione peroxidase levels between HD, CAPD, and control groups.

FIGURE 4.  Comparison of superoxide dismutase levels between patients on HD, SAPD, and control groups.

TABLE 4.  Results of Pearson's correlation

	r	p
MDA & EF	−0.380	0.001
SOD & SKB	−0.265	0.011
SOD & DKB	−0.230	0.028
SOD & P	−0.327	0.001
SOD & PTH	−0.259	0.013
SOD & CRP	−0.235	0.024
SOD & Fibrinojen	−0.342	0.001
SOD & T. Kolesterol	−0.249	0.017

FIGURE 5.  MDA levels of male and female patients.