Effect of rosiglitazone on cisplatin-induced nephrotoxicity

Figures & data

TABLE 1.  Biochemical and histopathologic findings of the treatment groups; data are presented as median (range)

	Cis	Cis–Ros	Control	p
BUN (mg/dL)	70.5 (34–174)	29 (20–266)	15.5 (13–18)	*0.001 **0.005
Creatinin (mg/dL)	1.34 (0.35–3.3)	0.72 (0.35–3.1)	0.25 (0.23–0.27)	*0.006 **0.004
Acute tubular necrosis	3.2 (2.8–3.4)	3.5 (3–3.9)	0.9 (0.2–1.6)	*0.004 **0.004
Karyomegaly	2.7 (1.8–2.8)	2.8 (1–3.6)	0.9 (0.2–1.6)	*0.004 **0.004
Apoptosis	56 (37–136)	51 (26–167)	14 (6–22)	*0.004 **0.004

Notes: Cis, cisplatin; Ros, rosiglitazone.

*Cis vs. controls.

**Cis–Ros vs. controls.

FIGURE 1.  Representative PAS-staining sections in each group (40× magnification).

FIGURE 2.  Number of apoptotic cells in treatment groups. *p: 0.004, Group 1 vs. Group 3; #p > 0.005 Group 1 vs. Group 2; and **p: 0.004, Group 2 vs. Group 3.