Association of metabolic changes with mortality of patients treated by peritoneal dialysis or hemodialysis

Figures & data

TABLE 1. Demographic, anthropometric and clinical characteristics of the examined patients

Parameters	Total number of examined patients (n = 407)	Patients treated by HD (n = 232)	Patients treated by PD (n = 175)
Age (years) (mean ± SD)	65 ± 12.5	59 ± 12.08	71 ± 11.98
Gender (m/f)	242/165	150/82	92/82
BMI (kg/m^2) (mean ± SD)	20.6 ± 3.4	20.1 ± 3.45	21.2 ± 3.3
Waist girth (cm) (mean ± SD)	95 ± 13.2	90 ± 12.2	102 ± 9.8
Duration of dialysis (months) (mean ± SD)	24 ± 47.3	46 ± 54.4	11 ± 17.5
Smoking (yes/no)	81/326	55/177	26/149
Residual renal function (yes/no)	144/263	74/158	70/105
Co-morbid factors (yes/no)
CVD (yes/no)	185/222	94/138	91/84
Diabetes mellitus (yes/no)	91/316	21/211	70/105
Peripheral vascular diseases (yes/no)	72/335	28/204	44/131
Lethal outcome (%)	53	37	65

TABLE 2. Mortality of examined patients in relation to metabolic changes

Patient group	Patients without metabolic abnormalities	Patients with parameters of metabolic syndrome	Patients with parameters of malnutrition	Completed study	Lethal outcome	p-Value
HD (n)	76	118	37	122	86	<0.001
PD (n)	44	65	66	51	124	<0.001

Note: *Statistically significant difference.

FIGURE 1. Kaplan–Meier curve of survival in patients treated by HD and PD. Median of survival of HD patients was 108 months, confidence interval (95% CI 65–151). Median of survival of PD patients was 12 months, confidence interval (95% CI 8.7–15.3); p < 0.001.

TABLE 3. Cox regression analysis of the expected parameters of survival in the examined patients

Variable	Patients treated by HD		Patients treated by PD
	Beta	p-Value	Beta	p-Value
Metabolic syndrome	0.560	0.045	−0.055	0.83
Malnutrition	0.173	0.63	0.454	0.066
BMI (kg/m^2)	0.022	0.49	0.088	0.002
Waist girth (cm)	0.010	0.26	0.023	0.031
Hemoglobin g/L	−0.008	0.30	0.000	0.92
Phosphate (mmol/L)	−0.191	0.41	−0.318	0.095
Albumins (g/L)	0.037	0.31	−0.005	0.82
Cholesterol (mmol/L)	0.023	0.84	0.010	0.92
CVD	0.425	0.072	−0.138	0.46
Diabetes mellitus	−0.352	0.45	0.050	0.79
Smoking	0.330	0.21	0.338	0.17

Note: *Statistically significant difference.

FIGURE 2. Residual renal function as factor of survival in patients on the PD program.

FIGURE 3. Residual renal function as factor of survival in patients on the HD program.