Initial high peritoneal transport status is not a predictor of mortality in peritoneal dialysis patients

Figures & data

TABLE 1. Baseline characteristics of the patients according to peritoneal transport type (n = 551)

Variable	L (n = 24)	LA (n = 204)	HA (n = 271)	H (n = 52)	p-Value
Age	46.7 ± 13.8	46.4 ± 14.5	48.7 ± 14.3	53.1 ± 14.7	0.022^a
Men [n (%)]	3 (12.5)	65 (31.9)	121 (44.6)	23 (44.2)	0.001^b,^c
Body weight (kg)	50.5 ± 7.90	55.0 ± 9.98	55.9 ± 10.36	54.2 ± 9.78	NS
BMI (kg/m^2)	20.7 ± 2.5	21.9 ± 3.5	21.8 ± 3.3	21.7 ± 3.5	NS
Prevalence of DM [n (%)]	3 (12.5)	32 (15.7)	51 (18.8)	12 (23.1)	NS
Comorbidity index	0.29 ± 0.62	0.35 ± 0.61	0.42 ± 0.66	0.46 ± 0.67	NS
Serum Cr (mg/dL)	11.73 ± 2.88	9.80 ± 3.03	9.21 ± 2.82	8.53 ± 2.64	<0.001^a,^b
Serum BUN (mg/dL)	67.0 ± 22.8	60.6 ± 17.0	60.0 ± 17.9	59.2 ± 19.1	NS
Serum albumin (g/dL)	4.25 ± 0.62	4.03 ± 0.48	3.78 ± 0.45	3.41 ± 0.58	<0.001^d
Net drained volume (mL)	346.7 ± 229.6	331.3 ± 142.3	248.1 ± 167.2	174.4 ± 175.7	<0.001^d
nPNA (g/kg/day)	1.23 ± 0.36	1.21 ± 0.26	1.15 ± 0.27	1.13 ± 0.24	0.045^e
%LBM	69.3 ± 12.1	74.0 ± 13.6	73.3 ± 13.3	71.9 ± 14.3	NS
Kt/V peritoneum	1.80 ± 0.40	1.85 ± 0.34	1.73 ± 0.37	1.69 ± 0.32	0.001^a,^c
Kt/V kidney	0.38 ± 0.46	0.62 ± 0.49	0.61 ± 0.45	0.63 ± 0.49	NS
Kt/V total	2.18 ± 0.64	2.47 ± 0.56	2.34 ± 0.50	2.33 ± 0.55	NS
RRF (mL/min)	1.52 ± 1.56	3.03 ± 2.52	3.21 ± 2.51	3.06 ± 2.19	0.015^f

Notes: Difference between transport categories was determined by ANOVA or chi-square test, values are presented as mean ± SD.

H, high peritoneal transport status; HA, high-average peritoneal transport status; LA, low-average peritoneal transport status; L, low peritoneal transport status; NS, not significant (p > 0.05); BMI, body mass index; DM, diabetes mellitus; BUN, blood urea nitrogen; nPNA, normalized protein nitrogen appearance; %LBM, percentage of lean body mass; Kt/V, normalized whole body clearance; RRF, residual renal function.

^ap < 0.05 LA vs. H.

^bp < 0.05 L vs. LA, HA, H.

^cp < 0.05 LA vs. HA.

^dp < 0.05 H vs. HA, LA, L; HA vs. LA, L.

^eNo significant difference between each transport status.

^fp < 0.05 L vs. LA, HA.

TABLE 2. Determinants of baseline D/P Cr in patients on peritoneal dialysis

	Simple linear regression r	p-Value	Multiple linear regression β coefficient ± SE	p-Value
Age (years)	0.112	0.008	0.108 ± 0.08	0.01
Male	0.169	<0.001	0.165 ± 0.009	<0.001
Diabetes mellitus	0.059	NS
Comorbidity index	0.06	NS
nPNA	–0.093	0.029
%LBM	0.008	NS
Kt/V kidney	0.073	0.085	0.071 ± 0.009	0.088
RRF	0.092	0.03
BMI	0.029	NS
BSA	0.075	0.077

Notes: NS, not significant (p > 0.1); nPNA, normalized protein nitrogen appearance; %LBM, percentage of lean body mass; RRF, residual renal function; BMI, body mass index; BSA, body surface area.

FIGURE 1. Longitudinal values of D/P creatinine.

FIGURE 2. Longitudinal values of D/P creatinine in patients with initial different peritoneal transport status.

FIGURE 3. Patient survival curves. L, low transporter; LA, low-average transporter; HA, high-average transporter; H, high transporter.

TABLE 3. Cox regression analysis of the overall risk of all-cause mortality according to baseline prognostic factors in maintenance PD patients (n = 551)

Variable	Univariate hazard analysis	p	Multivariate hazard analysis	p
	Relative risk (95% CI)		Relative risk (95% CI)
Age (Y/O)	1.09 (1.08–1.11)	<0.001	1.06 (1.05–1.08)	<0.001
Male	1.13 (0.76–1.67)	0.531
DM	8.34 (5.63–12.35)	<0.001
Comorbidity index	4.44 (3.54–5.57)	<0.001	2.31 (1.76–3.03)	<0.001
Serum Cr (mg/dL)	0.82 (0.75–0.89)	<0.001
Serum albumin	0.20 (0.15–0.28)	<0.001	0.58 (0.39–0.87)	0.008
nPNA	0.24 (0.11–0.51)	<0.001
%LBM	0.92 (0.91–0.94)	<0.001	0.97 (0.96–0.99)	0.008
D4/P4 Cr	2.02 (0.34–12.0)	0.44
Net drained volume	1.00 (0.99–1.01)	0.902
K–Kt/V (urea/week)	0.41 (0.25–0.67)	<0.001
T–Kt/V (urea/week)	0.47 (0.31–0.70)	<0.001
RRF (mL/min)	0.927 (0.85–1.01)	0.084

Notes: DM, diabetes mellitus; nPNA, normalized protein nitrogen appearance; %LBM, percentage of lean body mass; D4/P4 Cr, dialysate-to-plasma creatinine ratio at 4 h; RRF, residual renal function.