Endocapillary glomerulonephritis secondary to human parvovirus B19 presenting with nephrotic syndrome: a report of two cases and a review of the literature

Figures & data

TABLE 1. Initial biochemical, hematological, and radiological investigations of both cases

	Patient A (Case-1)	Patient B (Case-2)
Biochemistry
ESR (mm/h)	21	24
CRP (mg/L)	21	<7
Serum creatinine (μmol/L)	122	80
Urea (mmol/L)	7.2	4.4
Serum albumin (g/L)	30	30
24-h urine protein (g)	2.42	6.78
24-h urine creatinine clearance (mL/min)	98	90
Hematology
Hemoglobin (g/dL)	11.4	10.2
Total white cell count (×10^9)	6.4	5.2
Radiology and Imaging
Chest radiograph	Normal	normal
2D echocardiogram	Normal	normal

TABLE 2. Initial microbiological and immunological investigations of both patients

	Patient A (Case-1)	Patient B (Case-2)
Microbiology
Throat swab culture	Negative	Negative
Blood cultures	Negative	Negative
Anti-streptolysin-O titer (ASOT)	Negative	Negative
HBsAg	Negative	Negative
Hepatitis-C antibody test	Negative	Negative
Anti-parvovirus IgM	Positive	Positive
Anti-parvovirus IgG	Positive	Positive
HIV I and II antigen and antibody	Negative	Negative
Immunology
Serum ANA	Negative	Negative
Anti-dsDNA	Negative	Negative
ANCA	Negative	Negative
Rheumatoid factor	Negative	Negative
Serum cryoglobulins	Negative	Negative
Complement levels (g/L)
C3 (0.75–1.65)	0.60	0.71
C4(0.20–0.66)	0.14	0.18
Serum immunoglobulins	Normal	Normal
Protein electrophoresis	Normal	Normal

FIGURE 1. (a) Patient 1: Light microscopy. (b) Patient 2: Immunostaining highlighted granular capillary loops with IgG, IgM, C3, and C1q.

FIGURE 2. A graphical representation of the resolution of proteinuria and the serum albumin levels of Case-1.

FIGURE 3. A graphical representation of the resolution of the proteinuria and serum albumin levels of Case-2.

Mori Y, Yamashita H, Umed Y, Association of Parvovirus B19 infection with acute glomerulonephritis in healthy adults: Case report and review of the literature. Clin Nephrol. 2002;57:69–73.

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