The proportion and metabolic effects of adiponectin multimeric isoforms in patients with chronic kidney disease on maintenance hemodialysis

Figures & data

TABLE 1. Antherometric and biochemical characteristics of non-diabetic HD patients

Number of subjects	71
Gender (M/F)	30/41
Age (years)	64 ± 9
Duration of HD (months)	99 ± 70
BMI (kg/m^2)	20.6 ± 2.7
Systolic blood pressure (mmHg)	148 ± 19
Diastolic blood pressure (mmHg)	76 ± 9
Total cholesterol (mg/dL)	163 ± 29
Triglycerides (mg/dL)	102 ± 29
HDL cholesterol (mg/dL)	49 ± 16
LDL cholesterol (mg/dL)	89 ± 24
Oxidized LDL cholesterol	10.2 ± 9.9
RLP cholesterol (mg/dL)	6.5 ± 4.1
High-sensitive CRP (mg/dL)	1.43 ± 1.98
HOMA-IR	1.70 ± 1.03

Note: Result are expressed as meas ± SD.

TABLE 2. The levels and ratios between adiponectin multimers and total adiponectin

	Female (n = 41)	Male (n = 30)	p-Value
Total (μg/mL)	15.84 ± 6.70	11.47 ± 5.93	p < 0.01
HMW (μg/mL)	9.42 ± 5.36	5.70 ± 3.74	p < 0.01
MMW (μg/mL)	2.99 ± 1.39	2.55 ± 1.38	p < 0.05
LMW (μg/mL)	3.44 ± 1.01	3.50 ± 1.25	n.s
HMW/Total	0.56 ± 0.10	0.46 ± 0.10	p < 0.001
MMW/Total	0.19 ± 0.05	0.19 ± 0.06	n.s
LMW/Total	0.24 ± 0.09	0.35 ± 0.12	p < 0.001

Note: Result are expressed as meas ± SD.

TABLE 3. Spearmann correlation between adionectin multimers and other parameter

Variables	Total	HMW	MMW	LMW
Age (years)	0.071	0.031	0.132	0.119
Duration of HD (months)	−0.030	−0.083	0.018	0.194
BMI (kg/m^2)	−0.570**	−0.546**	−0.524**	−0.276
Systolic blood pressure (mmHg)	0.082	0.087	0.001	0.227
Diastolic blood pressure (mmHg)	−0.069	−0.036	−0.047	0.016
Total cholesterol (mg/dL)	0.117	0.175	0.091	−0.075
Triglycerides (mg/dL)	−0.515**	−0.471**	−0.408**	−0.430**
HDL cholesterol (mg/dL)	0.558**	0.556**	0.510**	0.327
LDL cholesterol (mg/dL)	−0.053	0.002	−0.059	−0.162
Oxidized LDL cholesterol	0.006	−0.003	0.018	0.058
RLP cholesterol (mg/dL)	−0.085	−0.071	−0.088	−0.188
High-sensitive CRP (mg/dL)	−0.329**	−0.332**	−0.213	−0.319
HOMA-IR	−0.407**	−0.385**	−0.385**	−0.228

Notes: * p < 0.05, ** p < 0.01.

TABLE 4. Forward stepwise multiple regression analysis of dependent variable

Variables	β	Standard error	t	p	Variables	β	Standard error	t	p
Total-Ad					HMW-Ad
HDL-C	0.297	0.002	2.668	0.010	HDL-C	0.278	0.002	2.565	0.013
BMI	−0.326	0.009	−3.073	0.003	BMI	−0.341	0.013	−3.298	0.002
Sex	−0.247	0.048	−2.462	0.016	Sex	−0.296	0.065	−3.021	0.004
MMW-Ad					LMW-Ad
BMI	−0.446	0.008	−4.314	0.000	Log TG	−0.364	0.553	−3.407	0.001
Sex	−0.268	0.045	−2.590	0.012	Log hs-CRP	−0.278	0.226	−2.606	0.011

Note: Independent variables tested include age and sex, as well as parameters showing a significant relationship in univariate analysis.