Enhanced Peritubular Capillary Flow and Renal Function Can Be Accomplished in Normoalbuminuric Type 2 Diabetic Nephropathy

Figures & data

Table 1. Pre-treatment and post-treatment values of blood chemistries, renal function, and hemodynamics

	Pre-treatment	p-Value	Post-treatment	Normal
Blood chemistries
Mean fasting blood sugar (mg/dL)	139 ± 35	<0.01	109 ± 30	≤100
Hb A1c (%)	7.9 ± 1	<0.001	6 ± 0.7	≤5.7
Renal function
Serum creatinine (mg/dL)	0.8 ± 0.1	<0.01	0.7 ± 0.1	≤1
Creatinine clearance (mL/min/1.73 m^2)	83 ± 22	<0.001	101 ± 25	120
Fractional excretion of magnesium (FE Mg) (%)	3.8 ± 1.7	<0.001	2.7 ± 1.2	1.6 ± 0.6
Microalbumin/creatinine (µg/mg)	19 ± 22	0.07	10 ± 7	≤30
Hemodynamics
Renal plasma flow (mL/min/1.73 m^2)	443 ± 69	<0.001	523 ± 92	600
Glomerular filtration rate (mL/min/1.73 m^2)	89 ± 21	<0.05	102 ± 27	120
Peritubular capillary flow (mL/min/1.73 m^2)	354 ± 66	<0.01	414 ± 72	480
Mean arterial pressure (mmHg)	88 ± 9	<0.001	80 ± 7	≤83

Figure 1. Comparison between current diagnostic markers versus new diagnostic approach to screen for staging of chronic kidney disease.