A Case of Acute Renal Failure Caused by Hodgkin's Lymphoma: Concurrent Membranous Glomerulonephritis and Interstitial HL-CD 20 Lymphoid Infiltration

Figures & data

Table 1. Incidence and types of glomerulonephropathy associated with lymphoma.²⁰

	Non-Hodgkin's lymphoma	Hodgkin's lymphoma
MCD	7 (14%)	45 (47%)
MGN	5 (10%)	5 (5%)
FSGS	3 (6%)	6 (7%)
MPGN	12 (25%)	2 (2%)
MsPGN	2 (4%)	6 (6%)
Immunotactoid GN	4 (8%)	0
Nephrotic syndrome/other	16 (33%)	32 (33%)
Total	49 (100%)	96 (100%)

Note: MCD, minimal change disease; MGN, membranous glomerulonephritis; FSGS, focal segmental glomerulosclerosis; MPGN, membranoproliferative glomerulonephritis; MsPGN, mesangioproliferative glomerulonephritis.

Figure 1. Glomerular basement membrane thickening (yellow arrows) and mononuclear cell infiltration (arrows) in kidney interstitium (HE, ×200). HE, Hematoxylin eosinophil.

Figure 3. B-cell lymphocytes stained by antibodies CD20 infiltration (arrows) in kidney interstitium (ABP, CD20, ×200). ABP, avidin biotin peroxidase method.

Figure 2. Small T-cell lymphocytes stained by antibodies CD3 infiltration (arrows) in kidney interstitium (ABP, CD3, ×200). ABP, avidin biotin peroxidase method.

Figure 4. Reed–Sternberg cells and reactive small lymphocytes (arrows) in lymph node sections (HE, ×200). Inset: cytoplasmic CD30 positivity in Reed–Sternberg cells (ABP, CD30, ×400). ABP, avidin biotin peroxidase method. Hematoxylin eosinophil.

Figure 5. Reed–Sternberg cells (white arrows) and CD3-positive reactive small lymphocytes (yellow arrows) in lymph node sections (ABP, CD3, ×200). Inset: CD20-positive Reed–Sternberg cells (arrows) and CD20-positive reactive small B lymphocytes (yellow arrows) in lymph node sections (ABP, CD20, ×200). ABP, avidin biotin peroxidase method.

Mallouk A, Pham PT, Pham PC. Concurrent FSGS and Hodgkin's lymphoma: Case report and literature review on the link between nephrotic glomerulopathies and hematological malignancies. Clin Exp Nephrol. 2006;10(4):284–289.

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