Troponins in Acute Kidney Injury

Figures & data

Table 1. Clinical characteristics of all subjects and subjects with elevated troponin T or I.

	All subjects (n = 19) Mean ± SD	Elevated troponins (n = 6) Mean ± SD (p-values)
Age	57 ± 19.7	74 ± 6.7 (<0.01)
Males	79%	100% (0.18)
Ethnicity
European	47%	50%
Maori	26%	17%
Indian	11%	0%
Pacific people	11%	17%
Asian	5%	17%
Diabetes	11%	17% (0.54)
Peak creatinine (μmol/L)	450 ± 270	592 ± 333 (0.23)
Peak urea (mmol/L)	20 ± 13	25.0 ± 17 (0.50)
Abnormal ECG	47%	83% (≤0.01)
IHD history	16%	50% (0.02)

Note: p-Values: compared subjects with elevated troponins versus those with troponins within the reference intervals.

Table 2. Etiologies of acute kidney injury.

Diagnosis	Number
Medication (NSAID, gentamicin)	5
Glomerulonephritis (post-infectious, ANCA, Goodpasture’s glomerulonephritis)	4
Post-renal obstruction	2
Pre-renal	2
Acute tubular necrosis	2
Cast nephropathy	1
Tumor lysis	1
Pyelonephritis	1

Table 3. Clinical characteristics of subjects with elevated troponins.

				Creatinine
Subject	Age/sex	Ethnicity	Etiology of AKI	Baseline	Peak	Last	Abnormal ECG	IHD
A	77/M	Asian	Cast nephropathy	NA	444	175	First degree heart blockage	No
B	51/M	Maori	Goodpasture’s glomerulonephri-tis	844	949	852	Left ventricular hypertrophy	No
C	78/M	European	Gentamicin toxicity	NA	165	116	T-wave inversion	Yes
D	77/M	European	ANCA vasculitis	NA	729	397	Normal	No
E	74/M	European	Bilateral ureteric obstruction	NA	949	219	Q waves in inferior leads	Yes
F	79/M	Pacific	Dehydration	NA	315	NA	First degree heart blockage, ventricular ectopics	Yes

Figure 1. Time course for cardiac markers (troponin I, troponin T, and CKMB) for subjects with elevated troponin concentrations. 1, admission; 2, peak creatinine; 3, discharge. A, B, C, D, E, and F reflect the same patients as in Table 3. Dashed line = 0.03 μg/L (99th percentile). One value was omitted for visual clarity; it was a value of 0.24 μg/L for patient F.