DD Genotype of ACE Gene in Boys: May it be a Risk Factor for Minimal Change Nephrotic Syndrome?

Figures & data

Table 1. The distribution of ACE genotypes and allele frequencies in children with MCNS and controls.

	MCNS (%) n = 97	Controls (%) n = 144	Odds ratio (CI %)
Genotypes
II	12 (13)	13 (9)	1.4 (0.6–3.2)
ID	48 (49)	71 (49)	1.0 (0.6–1.6)
DD	37 (38)	60 (42)	0.8 (0.5–1.4)
Alleles
I	72 (37)	97 (34)	1.1 (0.7–1.7)
D	122 (63)	191 (66)	0.8 (0.5–1.2)

Note: ACE, angiotensin-converting enzyme; MCNS, minimal change nephrotic syndrome; OR, odds ratio; CI, confidence interval.

Table 2. The distribution of ACE genotypes and allele frequencies by gender in children with MCNS and controls.

Group		Girls	Boys	OR	95% CI
	Genotypes
Controls n (%)	II	6 (9)	7 (9.1)	–	–
	ID	31 (46.3)	40 (51.9)	1.106	0.337–3.625
	DD	30 (44.8)	30 (39)	0.857	0.258–2.852
MCNS n (%)	II	8 (20)	4 (7)	–	–
	ID	24 (60)	24 (42.1)	2.000	0.531–7.539
	DD	8 (20)	29 (50.9)	7.250	1.730–30.383
	Alleles
Controls n (%)	I	43 (32.1)	54 (35.1)	–	–
	D	91 (67.9)	100 (64.9)	0.875	0.536–1.430
MCNS n (%)	I	40 (50)	32 (28.1)	–	–
	D	40 (50)	82 (71.9)	2.562	1.408–4.665

Note: ACE, angiotensin-converting enzyme; MCNS, minimal change nephrotic syndrome; OR, odds ratio; CI, confidence interval.