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Laboratory Study

Affirmative Effects of Iloprost on Apoptosis during Ischemia–Reperfusion Injury in Kidney as a Distant Organ

, , , , , , , , , , , & show all
Pages 111-118 | Received 16 Aug 2011, Accepted 12 Oct 2011, Published online: 29 Nov 2011

Figures & data

Figure 1. Effects of iloprost on caspases-3, -8, and -9 in kidney as a distant organ. Treatment of iloprost in I/R + iloprost subjects decreased the caspase-3, -8, and -9 enzyme activities as compared with both the ischemia and the I/R groups. Even more, iloprost (10 μg kg–1) treatment in I/R + iloprost subjects decreased the caspase-3 enzyme activity as compared with the sham group. Values are expressed as means ± SEM.

Note: p < 0.05 was considered to be significant. *Significantly different from sham, **significantly different from ischemia, ***significantly different from I/R, and #significantly different from iloprost.

Figure 1. Effects of iloprost on caspases-3, -8, and -9 in kidney as a distant organ. Treatment of iloprost in I/R + iloprost subjects decreased the caspase-3, -8, and -9 enzyme activities as compared with both the ischemia and the I/R groups. Even more, iloprost (10 μg kg–1) treatment in I/R + iloprost subjects decreased the caspase-3 enzyme activity as compared with the sham group. Values are expressed as means ± SEM.Note: p < 0.05 was considered to be significant. *Significantly different from sham, **significantly different from ischemia, ***significantly different from I/R, and #significantly different from iloprost.

Figure 2. Effects of iloprost on SOD enzyme activity in kidney as a distant organ. Values are expressed as means ± SEM.

Note: p <0.05 was considered to be significant. *Significantly different from sham, **significantly different from ischemia.

Figure 2. Effects of iloprost on SOD enzyme activity in kidney as a distant organ. Values are expressed as means ± SEM.Note: p <0.05 was considered to be significant. *Significantly different from sham, **significantly different from ischemia.

Figure 3. Effects of iloprost on nitrite levels in kidney as a distant organ. Values are expressed as means ± SEM.

Note: p < 0.05 was considered to be significant. *Significantly different from sham.

Figure 3. Effects of iloprost on nitrite levels in kidney as a distant organ. Values are expressed as means ± SEM.Note: p < 0.05 was considered to be significant. *Significantly different from sham.

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