Increased Cardiac Troponin T Levels Are Related to Inflammatory Markers and Various Indices of Renal Function in Chronic Renal Disease Patients

Figures & data

Table 1. Patient characteristics by CKD stage.

Parameters	Overall (n = 104)	Stage 3 (n = 43)	Stage 4 (n = 61)	p-Value
Age, years (mean ± SD)	58 ± 15	56 ± 11	62 ± 14	0.043
Male (%)	65 (67%)	28 (65%)	37 (60%)	0.038
Weight, kg (mean ± SD)	72.6 ± 19.1	71.8 ± 14.4	73.9 ± 13.2	0.048
Etiology of ESRD^a				NS
Hypertension	42	19	23
Diabetes mellitus	37	14	13
Primary glomerulonephritis	9	5	4
Polycystic kidney disease	6	2	4
Chronic pyelonephritis	4	1	3
Tubulointerstitial nephritis	2	0	2
Unknown etiology	27	12	25
BUN	62.3 ± 15.8	51.6 ± 13.4	77.8 ± 19.4	0.026
Creatinine	10.6 ± 2.8	6.5 ± 1.9	15.7 ± 4.6	0.032
Glucose (g/dL)	108.4 ± 41.9	109.2 ± 31.2	112.3 ± 61.4	NS
Uric acid (mg/dL)	5.6 ± 1.3	5.2 ± 1.1	6.0 ± 1.8	0.029
Phosphate (mg/dL)	5.3 ± 1.8	5.1 ± 1.6	5.5 ± 1.9	NS
Total cholesterol (mg/dL)	167.4 ± 45.0	152.8 ± 43.0	182.3 ± 32.8	0.018
LDL cholesterol (mg/dL)	90.6 ± 33.6	87.9 ± 28.9	93.7 ± 38.4	0.027
Triglyceride (mg/dL)	167.3 ± 74.8	158.5 ± 72.6	182 ± 39.3	0.026
CRP (mg/L)	12.1 ± 10.5	10.3 ± 9.1	14.2 ± 12.7	0.031
GFR	44.6 ± 14.3	52.4 ± 7.6	26.5 ± 3.5	0.001
Hemoglobin (g/dL)	10.7 ± 1.3	11.8 ± 1.8	10.2 ± 1.0	0.024
Leukocyte ( per μL)	6634.0 ± 2500.5	6042.0 ± 2023.2	6845.0 ± 2687.7	NS
Platelet count (per mL)	195.5 ± 61.1	243.4 ± 41.2	189.4 ± 32.8	NS
RRI	0.68 ± 0.06	0.72 ± 0.04	0.64 ± 0.03	0.001
cTnT ≥ 0.01 μg/L, n (%)	56 (54)	24 (25)	32 (29)	0.01
LVMI (g/m^2)	142.4 ± 38.6	136.8 ± 21.8	153.8 ± 28.9	0.01

Notes: Data are given as the mean (SD) when Gaussian distributed or as the median (interquartile range) when not Gaussian distributed. NS, nonsignificant; CRP, C-reactive protein; GFR, glomerular filtration rate; RRI, renal resistive index; LVMI, left ventricular mass index.

^aSome patients had more than one etiology for their ESRD.

Table 2. Parameters related with increased cTnT levels.

Parameters	cTnT ≥ 0.01 μg/L (n = 56)	cTnT < 0.01 μg/L (n = 48)	p-Value
Uric acid	5.9 ± 1.2	5.1 ± 1.0	0.04
Total cholesterol (mg/dL)	188.4 ± 32.0	160.0 ± 28.3	0.02
CRP (mg/L)	14.5 ± 7.4	8.3 ± 6.8	0.00
Hemoglobin (g/dL)	10.1 ± 1.1	11.0 ± 0.9	0.01
Leukocyte (per μL)	7354.0 ± 1856.2	6256.7 ± 2834.9	0.00
GFR	26.6 ± 11.2	51.6 ± 8.3	0.00
RRI	0.74.6 ± 0.13	0.61 ± 0.0.1	0.03
Ejection fraction ≤40% (n%)	14.2	3.5	0.00
LVMI (g/m^2)	151.7 ± 28.4	129.5 ± 18.6	0.00

Figure 1. Relationship of serum cTnT concentrations with GFR in patients with CKD.