Roles of Human Urotensin II in Volume Resistance Hypertension in Peritoneal Dialysis Patients

Figures & data

Table 1.  Demographic data of the study population.

Number of patients	105
Male/female	50/55
Mean age (years)	61.07 ± 12.76
Body mass index (kg/m^2)	24.02 ± 4.58
Dialysis vintage (months)	30.09 ± 15.52
Etiology of uremia (%)
Glomerulonephritis	11.5%
Hypertension	21.7%
Diabetes mellitus	30.6%
Tubulointerstitial nephritis	13.0%
Other	13.6%
Unknown	14.5%

Table 2.  Clinical characteristics in the classified subgroups.

	Normotension group (NT)	Hypertension group (HT)
Number of patients	47	58
Male (%)	55.5	44.8
Diabetes mellitus (%)	38.9	39.5
BMI (kg/m^2)	23.03 ± 3.70	24.02 ± 4.58
Dialysis vintage (months)	31.56 ± 24.92	29.00 ± 14.54
Plasma sodium (mmol/L)	138.41 ± 3.14	138.75 ± 2.65
Urea nitrogen (mmol/L)	23.49 ± 4.98	21.53 ± 6.01
Creatinine (μmol/L)	844.81 ± 245.85	818.89 ± 289.56
pKt/V	1.28 ± 0.62	1.44 ± 0.5
rKt/V	0.47 ± 0.64	0.45 ± 0.63
tKt/V	1.75 ± 0.77	1.90 ± 0.55
ECW (L)	14.55 ± 2.89	17.55 ± 3.03
ICW (L)	15.42 ± 3.61	16.49 ± 3.43
TBW (L)	29.97 ± 6.10	34.03 ± 6.02
nECW (L/m)	9.00 ± 1.50	10.54 ± 1.65
OH (L)	2.01 ± 1.20	2.85 ± 1.66
Systolic pressure (mmHg)	110.74 ± 13.36	146.78 ± 14.88
Diastolic pressure (mmHg)	68.49 ± 12.60	83.12 ± 11.57
Diuretics DDD	0.03 ± 0.8	0.04 ± 0.5
Total DDD	2.6 ± 1.6	2.9 ± 1.4
hUII (pg/mL)	13.03 ± 5.74	10.71 ± 4.62

Notes: DDD, defined daily dose; pKt/V, peritoneal dialysis Kt/V; rKt/V, renal Kt/V; tKt/V, total Kt/V; BMI, body mass index; ECW, extracellular water; nECW, normal ECW; TBW, total body water; OH, overhydration; hUII, human urotensin II.

*p < 0.05 versus NT group.

Table 3.  Comparison of human urotensin II (hUII) among subgroups.

	NT-NV	NT-HV	HT-NV	HT-HV
Number of patients	17	30	30	28
Age (years)	62.29 ± 13.99	62.67 ± 11.38	62.43 ± 10.77	57.14 ± 15.03
Male (%)	55.2	55.6	50.0	39.3
Diabetes mellitus (%)	47.6	26.7	40.9	38.1
BMI (kg/m^2)	23.07 ± 3.40	23.01 ± 3.91	24.62 ± 5.04	23.39 ± 4.02
Dialysis vintage (months)	26.56 ± 17.92	34.31 ± 28.09	29.40 ± 15.14	28.53 ± 14.18
Urea nitrogen (mmol/L)	20.75 ± 4.45	21.27 ± 4.54	21.06 ± 5.24	22.04 ± 6.84
Creatinine (μmol/L)	809.40 ± 283.34	868.95 ± 220.43	805.64 ± 248.43	833.72 ± 334.36
Serum sodium (mmol/L)	138.0 ± 2.5	139.0 ± 2.6	138.0 ± 3.2	137.8 ± 3.3
Serum albumin (g/L)	39.87 ± 3.31	39.21 ± 3.16	38.44 ± 4.00	38.69 ± 4.81
pKt/V	1.40 ± 0.58	1.49 ± 0.65	1.55 ± 0.57	1.33 ± 0.39
rKt/V	0.66 ± 0.74	0.44 ± 0.53	0.43 ± 0.52	0.48 ± 0.75
tKt/V	2.06 ± 0.66	1.93 ± 0.78	1.98 ± 0.52	1.81 ± 0.65
hUII (pg/mL)	12.25 ± 5.28	13.47 ± 6.02	11.37 ± 4.49	10.00 ± 4.73
Total DDD	2.1 ± 1.6	3.1 ± 1.7	3.0 ± 1.8	2.8 ± 1.1

Notes: DDD, defined daily dose; pKt/V, peritoneal dialysis Kt/V; rKt/V, renal Kt/V; tKt/V, total Kt/V; BMI, body mass index; hUII, human urotensin II.

*p < 0.05 versus HT-HV group.