The Relationship of Visfatin Levels with Insulin Resistance and Left Ventricular Hypertrophy in Peritoneal Dialysis Patients

Figures & data

Table 1. Demographic, clinical, and biochemical characteristics of the study patients.

Parameters	Values
Male:female	44:43
Age (years)	48 ± 15 (19–73)
Systolic blood pressure (mmHg)	124.7 ± 28.1 (98–162)
Diastolic blood pressure (mmHg)	79.1 ± 13.7 (60–110)
BMI (kg/m^2)	27.2 ± 5.0 (18–36)
Waist/hip ratio	0.82 ± 0.10
PD durations (months)	46 ± 18 (26–64)
Renal diagnosis, n (%)
Chronic glomerulonephritis	24 (27%)
Polycystic kidney disease	20 (23%)
Interstitial nephritis	17 (20%)
Other or unknown etiologies	26 (30%)
BUN (mg/dL)	51.7 ± 13.5 (26–64)
Creatinine (mg/dL)	9.4 ± 2.5 (5.3–11.8)
Glucose (g/dL)	98.1 ± 32.3 (60–123)
Uric acid (mg/dL)	6.0 ± 1.9 (3.7–8.0)
Albumin (g/dL)	4.0 ± 0.4 (2.9–4.8)
Total cholesterol (mg/dL)	185.7 ± 50.0 (96.0–267.0)
LDL cholesterol (mg/dL)	97.9 ± 64.7 (0.0–14.0)
HDL cholesterol (mg/dL)	41.5 ± 35.0 (6.0–77)
Triglyceride (mg/dL)	213.6 ± 198.9 (51.0–442.0)
CRP (mg/L)	10.9 ± 10.1 (0–43)
Insulin (IU/L)	12.3 ± 11.4 (0.9–23.7)
HOMA-IR	2.6 ± 1.8 (0.8–4.4)
Hemoglobin (g/dL)	11.4 ± 1.4 (8.3–12.8)
Leukocyte count (per μL)	7.4 ± 2.4 (3.5–9.8)
Platelet count (per mL)	254.6 ± 74.2 (115–334)
Visfatin (ng/mL)	39.5 ± 13.5
Kt/V (week)	1.96 ± 0.44
Ejection fraction (%)	49.6 ± 8.6 (21–64)
LVID	151.8 ± 41.6
LVMI (g/m^2)	138.6 ± 25.6 (113–163)

Notes: Values are presented as mean ± SD (median) or %. BUN, blood urea nitrogen; HDL, high density lipoprotein; LDL, low density lipoprotein; CRP, C-reactive protein.

Figure 1. Box plots representing the distribution of serum visfatin levels in control insulin-resistant (IR) and noninsulin-resistant (non-IR) groups; Kruskal–Wallis test (p = 0.00).

Figure 2. Histogram for evaluation of data distribution for serum visfatin levels.

Table 2. Stepwise linear regression analysis with visfatin as dependent variable (n = 87, r² = 0.68).

	Visfatin
Independent variable	β	p
PD duration (month)	0.326	0.18
Creatinine (mg/dL)	−0.388	0.32
Total cholesterol (mg/dL)	−0.191	0.04
LDL cholesterol (mg/dL)	0.01	0.95
CRP (mg/L)	0.169	0.04
HOMA-IR	−0.673	0.42
Ejection fraction (%)	−0.191	0.59
LVMI (g/m^2)	0.182	0.02

Note: LDL, low density lipoprotein; CRP, C-reactive protein.

Table 3. Stepwise linear regression analysis with LVMI as dependent variable (n = 87, r² = 0.54).

	LVMI
Independent variable	β	p
Age (years)	0.238	0.18
PD duration (months)	0.218	0.53
SBP (mmHg)	0.198	0.03
Diastolic blood pressure (mmHg)	0.178	0.93
Total cholesterol (mg/dL)	−0.191	0.28
LDL cholesterol (mg/dL)	0.01	0.45
CRP (mg/L)	0.169	0.39
HOMA-IR	−0.673	0.41
Ejection fraction (%)	−0.534	0.43
Visfatin (ng/mL)	0.745	0.02