Effects of Lipoprotein-Associated Phospholipase A2 on Arginase/Nitric Oxide Pathway in Hemodialysis Patients

Figures & data

Table 1.  Demographic and laboratory data of HD patients and control subjects.

Variables	Controls	HD patients	p-Values
Number	15	43
Gender (M/F)	8/7	23/20
Age (years)	53.67 ± 6.29	52.90 ± 11.80	ns
BMI (kg/m^2)	27.32 ± 4.10	24.86 ± 3.92	<0.05
Albumin (mg/dL)	4.50 (4.40–4.50)	4.10 (3.82–4.30)	<0.001
Creatinine (mg/dL)	0.80 (0.60–0.88)	8.50 (6.77–9.38)	<0.001
Total cholesterol (mg/dL)	163.00 (150.00–178.75)	176.00 (155.00–221.00)	ns
hs-CRP (mg/dL)	1.20 (0.80–1.95)	4.30 (2.32–9.45)	<0.001
HDL-cholesterol (mg/dL)	60.13 ± 8.16	36.77 ± 8.03	<0.001
LDL-cholesterol (mg/dL)	95.00 (80.25–98.00)	105 (85.00–118.25)	<0.05
Triglycerides (mg/dL)	114.00 (71.50–125.75)	220.00 (162.75–298.75)	<0.001

Notes: Values are expressed as means ± SD or medians (25th–75th percentile). BMI, body mass index; hs-CRP, high-sensitivity C-reactive protein; HDL, high-density lipoprotein; LDL, low-density lipoprotein; ns, nonsignificant; HD, hemodialysis.

Table 2.  Lp-PLA2, arginase, and Nitrite levels of the study population.

Variables	Controls	HD patients	p-Values
Number	15	43
Lp-PLA2 (ng/mL)	160.00 (152.00–191.00)	233.00 (189.25–271.75)	<0.001
Arginase (U/L)	2.18 (1.78–2.59)	4.12 (3.21–7.34)	<0.001
Nitrite (μmol/L)	0.59 ± 0.10	0.40 ± 0.16	<0.01

Note: Values are expressed as means ± SD or medians (25th–75th percentile).

Table 3.  Correlation coefficients of Lp-PLA2, arginase, and nitrite levels of HD patients (n = 43) with other variables.

	Age (years)	BMI (kg/m^2)	Albumin (mg/dL)	Creatinine (mg/dL)	TC (mg/dL)	HDL-C (mg/dL)	LDL-C (mg/dL)	TG (mg/dL)	hs-CRP (mg/dL)	Arginase (U/L)	Nitrite (μmol/L)
Lp-PLA2 (ng/mL)	r = 0.317	r = 0.146	r = 0.015	r = 0.060	r = 0.351	r = −0.303	r = 0.479	r = 0.540	r = 0.232	r = 0.554	r = −0.532
	p = 0.038	p = 0.351	p = 0.926	p = 0.700	p = 0.021	p = 0.049	p = 0.001**	p = 0.001**	p = 0.135	p = 0.001**	p = 0.000**
Arginase (U/L)	r = 0.224	r = 0.086	r = 0.322	r = 0.039	r = 0.352	r = −0.247	r = 0.588	r = 0.295	r = 0.139	–	r = −0.600
	p = 0.149	p = 0.584	p = 0.035	p = 0.806	p = 0.020	p = 0.110	p = 0.000**	p = 0.055	p = 0.373		p = 0.000**
Nitrite (μmol/L)	r = −0.273	r = −0.130	r = −0.094	r = −0.148	r = −0.369	r = 0.194	r = −0.374	r = −0.350	r = −0.151	–	–
	p = 0.077	p = 0.136	p = 0.550	p = 0.345	p = 0.015	p = 0.214	p = 0.014	p = 0.021	p = 0.334	–	–

Notes: Lp-PLA2, lipoprotein-associated phospholipase A2; BMI, body mass index; TC, total cholesterol; HDL-C, high-density lipoprotein-cholesterol; LDL-C, low-density lipoprotein-cholesterol; TG, trigycerides; hs-CRP, high-sensitivity C-reactive protein.

*p < 0.05, **p < 0.001.