The Relationship between Apelin and Parathyroid Hormone in Hemodialysis Patients

Figures & data

Table 1.  Patient characteristics and serum parameters according to PTH levels.

	Healthy subjects (N = 15)	All patients (N = 24)	PTH <300 pg/mL (N = 13)	PTH >300 pg/mL (N = 11)
Age (years)	51.3 (13.5)	54.2 (14.4)	53.7 (13.3)	54.8 (16.3)
Gender (M/F)	6/9	15/9	10/3	5/6
BMI (kg/m^2)	26.3 ± 3.7	25.0 (4.1)	24.0 (3.2)	26.2 (4.9)
WC (cm)	87.0 (13.0)	92.0 (15.0)	94.2 (11.5)	88.5 (19.7)
TSF (mm)	18.3 (5.3)	16.5 (5.6)	16.9 (6.3)	16.0 (4.5)
% fat body mass	32.0 (3.6)	29.8 (10.2)	30.3 (8.2)	29.4 (12.4)
Albumin (mg/dL)	–	3.87 (0.28)	3.9 (0.2)	3.7 (0.3)
Phosphorus (mg/dL)	–	4.4 (1.3)	4.2 (1.3)	4.7 (1.3)
Creatinine (mg/L)	–	9.9 (2.5)	9.2 (3.0)	10.8 (1.4)
Pre urea (mg/dL)	–	149.2 (27.5)	140.8 (29.6)	159.0 (22.3)
Hemoglobin (g/dL)	–	10.9 (1.2)	10.5 (1.18)	11.4 (1.2)
Glucose (mg/dL)	–	132.0 (53.8)	145.0 (68.7)	112.0 (28.2)

Table 2.  Apelin levels and bone densities according to PTH level.

	Healthy subjects	Mean ± SD (N = 23)	PTH <300 pg/mL (N = 13)	PTH >300 pg/mL (N = 11)^†
PTH (pg/mL)	53.6 (18.5)	548 (538.8)^§	149.2 (76.9)	1019.2 (458.0)*
Apelin (ng/mL)	0.83 (0.23)	0.80 (0.58)	0.5 (0.15)^§	1.16 (0.7)*
Total BMD (g/cm^3)	–	1.11 (0.17)	1.10 (0.15)	1.13 (0.2)
Lumbar spine BMD (g/cm^3)	–	1.07 (0.26)	1.05 (0.22)	1.10 (0.32)

Notes: *p < 0.05 between patients; ^§p < 0.05 between patients and healthy subjects.

†According to National Kidney Foundation, PTH levels >300 pg/mL indicate hyperparathyroidism.

Figure 1.  Correlation between PTH and plasma apelin levels (r = 0.66, p = 0.0001) in HD patients.

Figure 2.  Plasma apelin levels in HD patients with hyperparathyroidism compared with that in HD patients without hyperparathyroidism (p = 0.003).