Association of Inflammatory Biomarkers with Metabolic Syndrome in Hemodialysis Patients

Figures & data

Table 1. The clinical characteristics of the HD patients with or without metabolic syndrome (MeS).

	Total (n = 153)	No MeS (n = 62)	MeS (n = 91)	p-Value
Gender (male)	84 (54.9)	41 (66.1)	43 (47.3)	0.021
Age (year)	58.3 (15.8)	53.6 (19.1)	61.4 (12.1)	0.002
Hemodialysis duration (month)	64.3 (56.8)	85.5 (73.7)	49.8 (35.5)	<0.001
Waist circumference (cm)	89.6 (18.9)	81.2 (11.3)	95.3 (20.9)	<0.001
Body mass index (kg/m^2)	25.9 (4.6)	24.9 (4.9)	26.5 (4.4)	0.038
Systolic blood pressure (mm Hg)	126.4 (22.1)	118.7 (18.5)	131.4 (22.9)	<0.001
Diastolic blood pressure (mm Hg)	81.4 (7.9)	78.8 (6.5)	83.1 (8.4)	0.001
Fasting plasma glucose (mg/dL)	107.9 (50.2)	86.5 (18.6)	122.5 (59.1)	<0.001
Hemoglobin A1c (g/dL)	6.5 (1.6)	5.8 (0.9)	7.0 (1.7)	<0.001
Triglyceride (mg/dL)	133.3 (65.3)	109.9 (57.3)	149.2 (65.9)	<0.001
Total cholesterol (mg/dL)	126.9 (40.4)	125.9 (42.9)	127.6 (38.9)	0.805
HDL-C (mg/dL)	32.5 (11.4)	38.0 (14.7)	28.7 (6.2)	<0.001
LDL-C (mg/dL)	98.1 (45.9)	99.6 (40.9)	97.0 (49.2)	0.738
hsCRP (mg/dL)	2.1 (1.7)	1.7 (1.6)	2.3 (1.7)	0.03
Ferritin (μg/L)	357.7 (266.4)	282.6 (202.5)	409.4 (292.7)	0.004
Albumin (g/dL)	3.8 (0.4)	3.9 (0.4)	3.8 (0.4)	0.361
Transferrin (mg/dL)	203.5 (60.8)	199.2 (58.8)	206.5 (62.3)	0.475
Uric acid (mg/dL)	6.5 (1.2)	6.6 (1.2)	6.5 (1.2)	0.396

Notes: MeS was defined using the ATP-III.

*n (%).

Table 2. Relationship between inflammation biomarkers and metabolic syndrome (MeS) components.

		hsCRP (mg/dL)		Ferritin (μg/L)		Albumin (g/dL)		Transferrin (mg/dL)		Uric acid (mg/dL)
MeS component	n	Mean (SD)	p	Mean (SD)	p	Mean (SD)	p	Mean (SD)	p	Mean (SD)	p
Low HDL-C
Absent	22	1.8 (1.7)		342.6 (350.9)		4.1 (0.5)		191.4 (66.9)		6.3 (1.1)
Present	131	2.1 (1.7)	0.41	360.2 (251.0)	0.78	3.8 (0.4)	0.01	205.5 (59.7)	0.32	6.5 (1.2)	0.42
Hypertension
Absent	45	2.0 (1.6)		300.2 (180.2)		3.9 (0.4)		194.4 (61.5)		6.7 (1.2)
Present	108	2.1 (1.7)	0.82	378.4 (291.9)	0.10	3.8 (0.4)	0.47	207.2 (60.7)	0.25	6.4 (1.1)	0.11
Hyperglycemia
Absent	67	1.7 (1.5)		306.3 (204.5)		3.9 (0.4)		210.9 (67.4)		6.6 (1.1)
Present	86	2.3 (1.8)	0.02	397.1 (300.8)	0.04	3.8 (0.4)	0.06	197.6 (54.8)	0.18	6.4 (1.2)	0.30
Hypertriglyceridemia
Absent	96	1.9 (1.6)		339.2 (281.6)		3.8 (0.4)		198.0 (56.5)		6.6 (1.2)
Present	57	2.2 (1.9)	0.38	389.4 (237.3)	0.26	3.9 (0.4)	0.15	212.9 (67.2)	0.15	6.4 (1.2)	0.57
Abdominal obesity
Absent	109	1.9 (1.7)		324.8 (226.6)		3.8 (0.4)		197.5 (56.5)		6.6 (1.2)
Present	44	2.3 (1.6)	0.18	438.4 (334.8)	0.2	3.8 (0.4)	0.85	218.8 (69.2)	0.05	6.3 (1.2)	0.24

Note: MeS was defined using the ATP-III.

Figure 1. Linear relation between increase in hsCRP levels and the number of metabolic syndrome (MeS) components.