The Effects of Vitamin E-Coated Membrane Dialyzer Compared to Simvastatin in Patients on Chronic Hemodialysis

Figures & data

Table 1. Laboratory parameters of the patient groups at baseline and after 3 and 6 months of treatment with VEM versus simvastatin.

		VEM		Simvastatin
Parameters	Baseline	At 3 months	At 6 months	At 3 months	At 6 months
Albumin (g/dL)	3.9 ± 0.5	3.9 ± 0.3	4.1 ± 0.3	3.8 ± 0.2	3.8 ± 0.4
T-C (mg/dL)	234 ± 23	231 ± 20	238 ± 20	172 ± 24	166 ± 43
HDL-C (mg/dL)	39 ± 16	38 ± 6	42 ± 8	40 ± 10	40 ± 16
LDL-C (mg/dL)	152 ± 24	148 ± 19	153 ± 13	103 ± 22	97 ± 33
Triglycerides (mg/dL)	215 ± 74	224 ± 67	218 ± 72	146 ± 50	147 ± 40
ApoA1 (g/L)	110 ± 20	111 ± 13	113 ± 18	130 ± 23	130 ± 24
ApoB (g/L)	133 ± 33	129 ± 46	132 ± 35	122 ± 32	104 ± 35
ApoB/A	1.2 ± 0.3	1.2 ± 0.2	1.18 ± 0.3	0.9 ± 0.3	0.8 ± 0.3
Lp(a) (μmol/L)	9.2 ± 12.8	9.0 ± 6.1	8.9 ± 7.0	7.7 ± 4.0	4.4 ± 1.6
CRP (mg/L)	7.9 ± 5.3	5.9 ± 1.7	4.2 ± 2.3	7.4 ± 5.3	3.3 ± 0.6
hsIL-6 (pg/mL)	5.8 ± 4.1	5.0 ± 2.8	4.1 ± 3.8	5.1 ± 3.8	2.0 ± 1.2
sICAM-1 (ng/mL)	429 ± 118	304 ± 75	314 ± 77	415 ± 119	320 ± 74
sVCAM-1 (ng/mL)	2671 ± 720	2448 ± 683	2686 ± 1257	2653 ± 695	1711 ± 464
sE-selectin (ng/mL)	82 ± 34	82 ± 38	90 ± 40	82 ± 24	86 ± 33
MCP-1 (ng/mL)	503 ± 76	499 ± 81	492 ± 99	484 ± 64	486 ± 80
oxLDL (U/L)	45 ± 13	43 ± 9	31 ± 9	41 ± 11	34 ± 5
sFas (pg/mL)	22013 ± 5283	19548 ± 5286	18802 ± 5075	19548 ± 5286	17518 ± 4161
sFasL (pg/mL)	95 ± 26	100 ± 26	104 ± 41	105 ± 55	91 ± 38

Notes: ApoA1, apolipoprotein A1; ApoB, apolipoprotein B; CRP, C-reactive protein; HDL-C, high-density lipoprotein cholesterol; hsIL-6, high-sensitivity interleukin-6; LDL-C, low-density lipoprotein cholesterol; Lp(a), lipoprotein-a; MCP-1, monocyte chemoattractant protein-1; oxLDL, oxidized low-density lipoproteins; sE-selectin, soluble E-selectin; sFas, soluble Fas; sFasL, soluble Fas ligand; sICAM-1, soluble intercellular adhesion molecule-1; sVCAM-1, soluble vascular cell adhesion molecule-1. Data are presented as mean ± SD.

*p < 0.05 compared to baseline.

Table 2. Comparison of 6-month changes in the parameters studied in patients treated with VEM versus simvastatin.

Parameter	VEM	Simvastatin	∆	Comparison 95% CI	p-Value
T-C (mg/dL)	4 ± 14	−56 ± 24	60	40 to 84	0.0001
LDL-C (mg/dL)	1 ± 18	−47 ± 23	48	18 to 72	0.004
Triglycerides (mg/dL)	3 ± 7	−68 ± 54	71	30 to 128	0.008
ApoA1 (g/L)	3 ± 24	7 ± 20	−4	−25 to 22	0.89
ApoB (g/L)	−1 ± 32	−16 ± 36	15	−11 to 72	0.13
ApoB/A	−0.02 ± 0.25	−0.2 ± 0.2	0.18	−0.08 to 0.5	0.23
Lp(a) (μmol/L)	−0.3 ± 2.7	−2.9 ± 7.2	2.6	−2.4 to 9.6	0.21
CRP (mg/L)	−3.7 ± 4.1	−3.3 ± 4.6	−0.4	−4.7 to 5.4	0.87
hsIL-6 (pg/mL)	−1.7 ± 7.0	−1.7 ± 1.6	0	−5.0 to 5.9	0.86
sICAM-1 (ng/mL)	−115 ± 69	−136 ± 158	21	−102 to 205	0.48
sVCAM-1 (ng/mL)	−15 ± 174	−830 ± 843	652	294 to 2686	0.02
oxLDL (U/L)	−14 ± 15	−9.2 ± 7.7	−4.8	−19 to 11	0.55
sFas (pg/mL)	−3211 ± 850	−4495 ± 780	1284	510 to 1910	0.04

Notes: ApoA1, apolipoprotein A1; ApoB, apolipoprotein B; CRP, C-reactive protein; hsIL-6, high-sensitivity interleukin-6; LDL-C, low-density lipoprotein cholesterol; Lp(a), lipoprotein-a; oxLDL, oxidized low-density lipoproteins; sFas, soluble Fas; sICAM-1, soluble intercellular adhesion molecule-1; sVCAM-1, soluble vascular cell adhesion molecule-1. Data are expressed as mean ± SD. Comparison of mean differences (with 95% confidence intervals of the difference) for each variable were estimated using Student’s t-test: ∆ negative numbers for all variables favor VEM treatment, while positive numbers favor simvastatin treatment.