Comparative Study on the Inhibitory Effects of α-Tocopherol and Radon on Carbon Tetrachloride-Induced Renal Damage

Figures & data

Figure 1. Effects of radon (A) and α-tocopherol (B) on renal function-associated parameters in the serum of CCl₄-administrated mice. Each value indicates the mean ± 95% confidence intervals. The number of mice per experimental point is—six to eight.

Note: *p < 0.05 versus CCl₄, ^###p < 0.01 versus control.

Figure 2. Effects of radon (A) and α-tocopherol (B) on oxidative damage-associated parameters in the kidney of CCl₄-administrated mice. Each value indicates the mean ± 95% confidence intervals. The number of mice per experimental point is—five to seven.

Note: *p < 0.05, **p < 0.01 versus CCl₄, ^###p < 0.001 versus control.

Figure 3. Effect of radon (H) and α-tocopherol (I) on CCl₄-induced renal damage in mouse: (A) control, (B) CCl₄, (C) α-tocopherol 100 mg/kg + CCl₄, (D) α-tocopherol 300 mg/kg + CCl₄, (E) α-tocopherol 500 mg/kg + CCl₄, (F) radon 1000 Bq/m³ + CCl₄, (G) radon 2000 Bq/m³ + CCl₄. Mouse kidneys were examined histologically. The length of the scale bar is 100 μm. All samples were stained with H&E. The arrow indicates dilatation of Bowman’s space with glomerular atrophy. Each value indicates the mean ± 95% confidence intervals. The number of mice per experimental point was—five to six.

Note: *p < 0.05, **p < 0.01 versus CCl₄, ^###p < 0.001 versus control.

Figure 4. Effects of radon (A) and α-tocopherol (B) on antioxidative-associated parameters in the kidney of CCl₄-administrated mice. Each value indicates the mean ± 95% confidence intervals. The number of mice per experimental point is—six to eight.

Note: *p < 0.05, **p < 0.01, ***p < 0.001 versus CCl₄, ^##p < 0.01, ^###p < 0.001 versus control.