Congenital Megacalycosis with IgA Nephropathy: A Case Report and Review of the Literature

Figures & data

Figure 1.  Magnetic resonance urography revealed calyceal dilatation, increased number of calyces, and normal ureters and bladder.

Figure 2.  Glomeruli had no significant alterations light microscopically [(A) hematoxylin and eosin stain, ×200 magnification and (B) Masson’s trichrome stain, ×400 magnification].

Figure 3.  Mild tubular atrophy with interstitial fibrosis is noted at right side of the picture (Jone’s methanamine silver stain, × 200 magnification). Inset shows deposition of IgA in the mesangial regions (imunofluorescence, fluorescein isothiocyanate-conjugated anti-IgA antibody ×400).

Table 1.  Clinical and demographic characteristics of the cases with congenital megacalycosis described in the literature.

Author(s), year	Age/gender	Calycosis	Clinical presentation
Reyes and Trejo, 1982^15	Newborn	Bilateral	n/a
Vargas and Lebowitz 1986^7	Six patients ages between 8 and 22 years three boys and three girls	Unilateral in all patients	Urinary tract infection (4/6), flank pain (1/6), hematuria (1/6) and megaureter in all patients
Shieh et al.,1990^16	Seven patients ages between 7 and 14 years Five boys and two girls	Three bilateral, four unilateral	Asymptomatic (6/7) and hematuria (1/7)
Parlaktas et al., 2004^10	20-year-old male	Bilateral	Bilateral lombar pain
Kasap et al.,	17-year-old male	Bilateral	Urinary tract infection
2005^8	4-month-old boy	Bilateral	Antenatal hydronephrosis
Redman and Neeb, 2005^12	13-year-old boy	Unilateral	Gross hematuria after trauma
Alivanis et al., 2006^9	22-year-old male	Bilateral	Urinary tract infection
Kleszczynski et al., 2006^17	10-year-old girl	Bilateral	Urinary tract infection
Alivanis et al., 2006^9	22-year-old male	Bilateral	Urinary tract infection
Pieretti et al.,	2-year-old boy	Bilateral	Antenatal hydronephrosis
2009^11	9-month-old girl	Unilateral	Accidentally in ultrasound
Bekele and Sanchez, 2010^18	8-year-old boy	Unilateral	Antenatal hydronephrosis

Note: n/a, not available.

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