Mononuclear Inflammatory Infiltrate and Microcirculation Injury in Acute Rejection: Role in Renal Allograft Survival

Figures & data

Table 1. Description of clinical features.

Features	Values
n	47
Recipients’ age (yr, mean ± SD)	38.9 ± 15.1
Recipients’ gender (%): male	48.9
Donor (%): living	51
HLA pretransplant mismatch (mean ± SD)	2.21 ±.1.10
Delayed graft function (%)	40
SCr at the time of biopsy (mg/dl, mean ± SD)	4.61 ± 3.79
SCr at the last visit (mg/dl, mean ± SD)	2.89 ±.2.52
Follow-up (mo, mean ± SD)	46.9 ± 46.1
Graft loss (%)	31

Notes: AR, acute rejection; Scr; serum creatinine.

Figure 1. Associations between C4d staining and peritubular/interstitial (A) and glomerular (B) monocytes/macrophages.

Table 2. Pretransplant panel-reactive antibodies (PRA) and number of mismatches to each group.

	PRA (n)
	Unknowledge	0%	≤10%	10–50%	≥50
Group 1
<50 Mo per HPF	6	12	1	2	1
≥50 Mo per HPF	5	13	3	4	0
Group 2
<4 gMo	7	15	2	3	1
≥4gMo	4	10	2	3	0
		Mismatches (n)
		0 ≤ m ≤2	m = 3	m ≥ 4
Group 1
<50 Mo per HPF		6	15	1
≥50 Mo per HPF		4	18	3
Group 2
<4 gMo		7	19	2
≥4 gMo		3	14	2

Notes: p > 0.05: there was no statistically significant difference between the above data (mismatches and PRA) and the groups.

n, number of cases; m, number of mismatches.

Figure 2. Graft survival time curve related to glomerular monocytes/macrophages (Kaplan–Meier method; log-rank test).