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Research Article

Protective effect of rutin on hexachlorobutadiene-induced nephrotoxicity

, , , , &
Pages 1151-1155 | Received 26 Mar 2013, Accepted 03 Jun 2013, Published online: 23 Jul 2013

Figures & data

Figure 1. Effects of rutin on concentration of serum urea (A) and creatinine (B) in rats treated with hexachlorobutadiene (HCBD). Rutin was administrated intraperitoneally 1 h before HCBD injection (100 mg/kg, i.p.). Control rats were received saline as vehicle. Data are shown as mean ± SEM (n = 6). #p < 0.001 compared to control; *p < 0.001 as compared with HCBD group.

Figure 1. Effects of rutin on concentration of serum urea (A) and creatinine (B) in rats treated with hexachlorobutadiene (HCBD). Rutin was administrated intraperitoneally 1 h before HCBD injection (100 mg/kg, i.p.). Control rats were received saline as vehicle. Data are shown as mean ± SEM (n = 6). #p < 0.001 compared to control; *p < 0.001 as compared with HCBD group.

Figure 2. Effects of rutin on concentration of urine glucose (A) and protein (B) in rats treated with hexachlorobutadiene (HCBD). Rutin was administrated intraperitoneally 1 h before HCBD injection (100 mg/kg, i.p.). Control rats were received saline as vehicle. Data are shown as mean ± SEM (n = 6). #p < 0.001 compared to control; *p < 0.001 as compared with HCBD group.

Figure 2. Effects of rutin on concentration of urine glucose (A) and protein (B) in rats treated with hexachlorobutadiene (HCBD). Rutin was administrated intraperitoneally 1 h before HCBD injection (100 mg/kg, i.p.). Control rats were received saline as vehicle. Data are shown as mean ± SEM (n = 6). #p < 0.001 compared to control; *p < 0.001 as compared with HCBD group.

Figure 3. Effect of rutin on lipid peroxidation in the kidney homogenate of rats treated with hexachlorobutadiene (HCBD). Rutin was administrated intraperitoneally 1 h before HCBD injection (100 mg/kg, i.p.). Control rats were received saline as vehicle. The lipid peroxidation level was estimated by measuring the concentration of malondialdehyde (MDA). Data are shown as mean ± SEM (n = 6). #p < 0.001 compared to control; *p < 0.001 as compared with HCBD group.

Figure 3. Effect of rutin on lipid peroxidation in the kidney homogenate of rats treated with hexachlorobutadiene (HCBD). Rutin was administrated intraperitoneally 1 h before HCBD injection (100 mg/kg, i.p.). Control rats were received saline as vehicle. The lipid peroxidation level was estimated by measuring the concentration of malondialdehyde (MDA). Data are shown as mean ± SEM (n = 6). #p < 0.001 compared to control; *p < 0.001 as compared with HCBD group.

Figure 4. Effect of rutin on total thiol content in the kidney homogenate of rats treated with hexachlorobutadiene (HCBD). Rutin was administrated intraperitoneally 1 h before HCBD injection (100 mg/kg, i.p.). Control rats were received saline as vehicle. Data are shown as mean ± SEM (n = 6). #p < 0.001 compared to control; *p < 0.01 as compared with HCBD group.

Figure 4. Effect of rutin on total thiol content in the kidney homogenate of rats treated with hexachlorobutadiene (HCBD). Rutin was administrated intraperitoneally 1 h before HCBD injection (100 mg/kg, i.p.). Control rats were received saline as vehicle. Data are shown as mean ± SEM (n = 6). #p < 0.001 compared to control; *p < 0.01 as compared with HCBD group.

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