Obesity in kidney transplant recipients: association with decline in glomerular filtration rate

Figures & data

Table 1. Characteristics of the sample distributed according to baseline BMI.

	Underweight	Normal	Overweight	Obese
Characteristics	(n = 31)	(n = 248)	(n = 120)	(n = 48)	p
Age (X ± DP)	32.7 ± 10.1	41.5 ± 11.8	47.2 ± 10.2	47.1 ± 9.2	<0.001*
Male gender (n/%)	7 (22.5%)	141 (56.8%)	80 (66.7%)	33 (68.7%)	<0.001#
Caucasian (n/%)	25 (80.6%)	217 (87.5%)	96 (80%)	40 (83.3%)	0.425#
Deceased donor (n/%)	23 (74.2%)	179 (72.2%)	96 (80%)	36 (75%)	0.453#
Re-RT (n/%)	2 (6.5%)	28 (11.3%)	9 (7.5%)	2 (4.2%)	0.326#
Hospitalizations (X ± DP)	3.8 ± 2.9	3.4 ± 2.7	3.9 ± 3.3	3.7 ± 2.8	0.504*
DM (n/%)	0 (0%)	16 (6.5%)	15 (12.5%)	6 (12.5%)	0.050#
HCV (n/%)	9 (29%)	38 (15.3%)	18 (15%)	8 (16.7%)	0.261#
CyA (n/%)	19 (61.3%)	171 (68.9%)	88 (73.3%)	26 (54.2%)	0.144#
Induction (n/%)	13 (41.9%)	85 (34.3%)	47 (39.5%)	21 (43.7%)	0.776#
ATG Induction (n/%)	3 (9.7%)	18 (7.3%)	8 (6.7%)	2 (4.2%)	0.776#
Class I >50 (n/%)	4 (12.9%)	11 (4.4%)	3 (2.5%)	4 (8.3%)	0.071#
Class II>50 (n/%)	5 (16.1%)	11 (4.4%)	6 (5%)	2 (4.2%)	0.054#

Re-RT = Retransplantation, DM = Diabetes Mellitus, HCV = Hepatitis C status, CyA = cyclosporine, ATG = Thymoglobulin.

*ANOVA.

#Chi-Square.

Table 2. Nutritional status before and one year after renal transplantation.

Period	Pre-RT, n(%)	Post-RT, n(%) underweight	Normal weight	Overweight	Obese	Total
Underweight	31 (6.9%)	12 (46.2%)	14 (53.8%)	0	0	26
Normal	248 (55.5%)	4 (1.8%)	150 (69.1%)	56 (25.8%)	7 (3.3%)	217
Overweight	120 (26.8%)	0	14 (13.5%)	64 (61.5%)	26 (25%)	104
Obesity	48 (10.7%)	0	1 (2.6%)	5 (13.2%)	32 (84.2%)	38
Total	447	16 (4.2%)	179 (46.5%)	125 (32.5%)	65 (16.9%)	385

Table 3. Nutritional status at baseline and outcomes at one and five years post transplantation.

Outcomes	Underweight	Normal	Overweight	Obesity	p*
DGF, n(%)	13 (41.9%)	97 (39.1%)	61 (50.8%)	26 (54.2%)	0.081
Early loss, n(%)	3 (9.7%)	8 (3.2%)	8 (6.6%)	6 (12.5%)	0.042
Wound complication, n(%)	4 (12.9%)	38 (15.3%)	22 (18.3%)	5 (10.4%)	0,603
AR, n(%)
1y	10 (38.5%)	75 (34.5%)	30 (28.8%)	10 (26.3%)	0.544
5y	6 (54.5%)	33 (30.3%)	20 (41.7%)	3 (27.3%)	0.245
Death, n(%)
1y	2 (6.4%)	15 (6.2%)	7 (5.8%)	3 (6.2%)	0.999
5y	4 (25%)	24 (16.9%)	10 (15.6%)	2 (12.5%)	0.790
NODAT, n(%)
1y	4 (15.4%)	27 (12.4%)	26 (25%)	10 (26.3%)	0.018
5y	2 (18.2%)	12 (11%)	14 (29.2%)	4 (36.4%)	0.017
Dyslipidemia, n(%)
1y	17 (65.4%)	163(75.1%)	77 (74%)	32 (84.2%)	0.383
n(%)
5y	7 (63.6%)	90 (82.6%)	34 (70.8%)	9 (81.8%)	0.240
Graft loss, n(%)
1y	5 (16.1%)	32 (13.2%)	19 (15.8%)	10 (20.8%)	0.568
n(%)
5y	8 (50%)	43 (30.3%)	27 (42.2%)	6 (37.5%)	0.217

DGF = delayed graft function, AR = acute rejection, NODAT = new onset diabetes after transplantation.

*Chi-Square.

Figure 1. Evolution of estimated GFR means related to nutritional status pre renal transplant.