Vascular disease in early stage of diabetic nephropathy

Figures & data

Table 1. Demonstrated renal function, renal hemodynamics and macrovascular disease index in early diabetic nephropathy.

	Healthy subject	p Value	Early diabetic nephropathy
I. Renal Function
Serum creatinine mg/dL	0.8 + 0.1	NS	1 + 0.2
Mean arterial pressure mmHg	79 + 5	0.001	90 + 11
Creatinine clearance   mL/min/1.73 m^2	117 + 13	<0.001	88 + 14
FE Mg %	2 + 0.2	<0.05	4.3 + 1
Microalbumin/creatinine ratio	<30 µg/mg	NS	7 + 6
II. Microvascular Index
Renal plasma flow   mL/min/1.73 m^2	585 + 30	<0.01	395 + 41
Glomerular filtration rate   mL/min/1.73 m^2	116 + 14	<0.01	86 + 16
Peritubular capillary flow   mL/min/1.73 m^2	479 + 26	<0.001	322 + 33
Afferent arteriolar resistance (RA)   dyne·s·cm^−5	2332 + 108	<0.05	5057 + 861
Efferent arteriolar resistance (RE)   dyne·s·cm^−5	3012 + 130	<0.05	4997 + 483
III. Macrovascular Index:
Cardio-Ankle Vascular Index (CAVI)
Arterial stiffness	7.2 + 1	<0.001	9.3 + 1.2
Estimated age of artery	39 + 15		66 + 11
	p < 0.05		p < 0.05
Actual age of patients (years)	41 + 14		63 + 11