NGAL and NT-proBNP levels in diabetic patients with macroproteinuria

Figures & data

Table 1. The general characteristics and clinical parameters of the study groups.

	Patients Mean ± Std. Deviation	Controls Mean ± Std. Deviation	p
Gender (female)	8 (40%)	10 (50%)	0.751
Age (years)	62.2 ± 11.2	58.8 ± 14.8	0.341
BMI (kg/m^2)	29.2 ± 3.8	27.4 ± 3.4	0.064
NT-proBNP (pg/mL)	3788.9 ± 8303.3	102.2 ± 88.9	0.000
Serum NGAL (ng/mL)	60.1 ± 12.8	47.1 ± 22.5	0.049
Urine DNGAL (ng/mL)	60.1 ± 19.1	5.8 ± 5.7	0.000

Table 2. Comparison of the repeated measurements.

	At the baseline	At the 4th month	At the 8th month
BUN (mg/dL)	41.9 ± 14.8	47.1 ± 25.9	44.7 ± 16.3	NS
Urine albumin/creatinine (g/day)	6.8 ± 5.1	6.0 ± 5.3	7.8 ± 8.2	^b,c
Serum creatinine (mg/dL)	2.6 ± 1.1	2.8 ± 1.4	3.1 ± 1.4	^b
Serum albumin (mg/dL)	3.3 ± 0.6	3.2 ± 0.7	3.1 ± 0.6	NS
Serum calcium (mg/dL)	8.8 ± 0.7	8.7 ± 0.7	8.5 ± 0.7	^b
Serum phosphorus (mg/dL)	4.2 ± 0.7	4.3 ± 0.8	4.4 ± 0.9	NS
Parathyroid hormone (pg/mL)	274.4 ± 213.6	199.5 ± 139.6	225.0 ± 175.9	^a
BMI (kg/m^2)	29.2 ± 3.8	28.5 ± 4.9	28.8 ± 4.4	NS
NT-proBNP (pg/mL)	3788.9 ± 8303.3	4514.4 ± 9211.3	8292.7 ± 12,393.0	^b,c
Serum NGAL (ng/mL)	60.1 ± 12.8	66.8 ± 8.9	68.5 ± 6.3	^a,c
Urine DNGAL (ng/mL)	60.1 ± 19.1	60.1 ± 25.1	62.0 ± 22.6	NS
eGFR	29.6 ± 12.0	27.8 ± 13.7	22.9 ± 10.4	^b,c
logbnp	6.6 ± 1.8	6.9 ± 1.8	7.7 ± 2.0	^b,c
Systolic blood pressure (mm/Hg)	150.8 ± 14.5	156.1 ± 14.0	148.9 ± 11.1	^c
Diastolic blood pressure (mm/Hg)	89.4 ± 8.2	88.3 ± 9.7	88.9 ± 7.1	NS

^aComparison between the baseline and at the 4th month measurement is p < 0.05.

^bComparison between the baseline and at the 8th month measurement is p < 0.05.

^cComparison between at the 4th month and at the 8th month measurement is p < 0.05.

NS: nonsignificant p > 0.05.

Table 3. The correlation analysis results.

	The baseline			The 4th month			The 8th month
		eGFR	ACR		eGFR	ACR		eGFR	ACR
eGFR	r	1.000	−0.076	Serum albumin	1.000	−0.058	Serum albumin	1.000	−0.364
	p	–	0.750		–	0.808		–	0.115
ACR	r	−0.076	1.000	ACR	−0.058	1.000	ACR	−0.364	1.000
	p	0.750	–		0.808	–		0.115	–
Serum albumin	r	0.075	−0.792	Serum albumin	0.075	−0.716	Serum albumin	0.401	−0.531
	p	0.752	0.000		0.755	0.000		0.080	0.016
NT-proBNP	r	0.308	0.451	NT-proBNP	0.006	0.489	NT-proBNP	−0.165	0.359
	p	0.187	0.046		0.980	0.029		0.486	0.120
Serum NGAL	r	−0.231	−0.324	Serum NGAL	−0.172	−0.008	Serum NGAL	−0.230	0.478
	p	0.326	0.164		0.468	0.972		0.329	0.033
Urine NGAL	r	−0.376	0.171	Urine NGAL	−0.044	−0.027	Urine NGAL	−0.471	0.015
	p	0.102	0.470		0.855	0.910		0.036	0.950
logbnp	r	0.308	0.451	logbnp	0.006	0.489	logbnp	−0.165	0.359
	p	0.187	0.046		0.980	0.029		0.486	0.120
Systolic blood pressure	r	−0.436	0.329	Systolic blood pressure	−0.471	0.267	Systolic blood pressure	0.440	0.114
	p	0.071	0.182		0.048	0.304		0.068	0.652
Diastolic blood pressure	r	−0.004	0.290	Diastolic blood pressure	0.068	0.620	Diastolic blood pressure	−0.488	0.277
	p	0.988	0.297		0.789	0.006		0.040	0.266

Urine albumin/creatinine: ACR.

log transformed NT-proBNP: logbnp.