Serum paraoxonase 1 status and its association with atherogenic indexes in gentamicin-induced nephrotoxicity in rats treated with coenzyme Q10

Figures & data

Table 1. Effect of coenzyme Q10 on TC, TG, LDL, HDL and VLDL and in nephrotoxic rats.

Parameter	Control	Nephrotoxic	Nephrotoxic +  coenzyme Q10
TG (mg/dL)	110.50 ± 28.84^a	162.29 ± 35.42	91.25 ± 28.16^a
TC (mg/dL)	62.00 ± 14.38	72.71 ± 14.58	81.50 ± 15.23^b
HDL (mg/dL)	34.33 ± 9.73^a	14.00 ± 3.42	24.75 ± 3.38^a,b
LDL (mg/dL)	5.56 ± 3.57^a	26.26 ± 10.14	38.50 ± 19.33^a
VLDL (mg/dL)	22.10 ± 5.77	32.46 ± 15.19	5.63 ± 2.82^b

Notes: Values are represented as mean ± SE coenzyme Q10.

^aSignificant change in comparison with nephrotoxic without treatment at p < 0.05.

^bSignificant change in comparison with control at p < 0.05.

Table 2. Effect of coenzyme Q10 on atherogenic index, atherogenic coefficient, and cardiac risk ratio in nephrotoxic rats.

Parameter	Control	Nephrotoxic	Nephrotoxic +  Coenzyme Q10
Atherogenic index ((Units) (log (TG/HDLC))	22.10 ± 5.77	32.43 ± 7.08	18.25 ± 8.58^b
Atherogenic coefficient (TC-HDLC/HDLC)	0.51 ± 0.11^a	1.07 ± 0.18	0.56 ± 3.21^a
Cardiac risk ratio (TC/HDL-C)	0.84 ± 0.22^a	4.93 ± 3.78	2.57 ± 1.43
Cardiac risk ratio (LDL/HDL-C)	1.84 ± 0.22^a	5.93 ± 3.78	3.56 ± 1.43

Notes: Values are represented as mean ± SE coenzyme Q10.

^aSignificant change in comparison with nephrotoxic without treatment at p < 0.05.

^bSignificant change in comparison with control at p < 0.05.

Table 3. Effect of coenzyme Q10 on serum lipid peroxidation and PON 1 activity in nephrotoxic rats.

Parameter	Control	Nephrotoxic	Nephrotoxic +  oleuropein
MDA (nmol/mg protein)	82.48 ± 20.40^a	128.18 ± 7.36	112.36 ± 27.52^b
PON 1 (nmol/min/mL)	77.84 ± 9.43^a	49.06 ± 4.10	64.43 ± 8.17^a

Notes: Values are represented as mean ± SE coenzyme Q10.

^aSignificant change in comparison with nephrotoxic without treatment at p < 0.05.

^bSignificant change in comparison with control at p < 0.05.

Figure 1. Correlation between maternal serum PON 1 activity and levels of HDL in nephrotoxic rats treated with coenzyme Q10 (r = −0.755, p = 0.000).

Figure 2. Correlation between maternal serum PON 1 activity and levels of AC (atherogenic coefficient (TC-HDLC/HDLC)) in nephrotoxic rats treated with coenzyme Q10 (r = −0.185, p = 0.035).

Figure 3. Correlation between maternal serum PON 1 activity and levels of CRR1 (cardiac risk ratio (TC/HDL-C)) in nephrotoxic rats treated with coenzyme Q10 (r = −0.236, p = 0.016).

Figure 4. Correlation between maternal serum PON 1 activity and levels of CRR2 (cardiac risk ratio (LDL/HDL-C)) in nephrotoxic rats treated with coenzyme Q10 (r = −0.314, p = 0.004).