Urinary biomarkers in assessing the nephrotoxic potential of gentamicin in solitary kidney patients after 7 days of therapy

Figures & data

Table 1. Comparative assessment of SK patients without other pathology (group A) versus healthy individuals with two kidneys (group B).

Parameter	SK patients without other pathology (n = 17) (group A)	Healthy individuals with two kidneys (n = 9) (group B)	p
Age, years	51.17 ± 9.39	54.77 ± 12.74	0.42
Sex
Male (%)	41.17 (n = 7)	22.22 (n = 2)	NS
Female (%)	58.82 (n = 10)	77.77 (n = 7)	NS
GFR, ml/min/1.73 m^2	71.01 ± 11.31	69.94 ± 13.92	0.83
Albumin urin/creat urine (mg/g)	17.27 ± 14.88	5.56 ± 3.38	0.006
NAG/creat urine (U/g)	2.89 ± 2.108	1.61 ± 0.82	0.038
Alfa-1-microglobulin urin/creat urine (mg/g)	2.88 ± 5.57	2.09 ± 1.09	0.096

Notes: The data are presented as average value ± standard deviation or number (%) of patients. Average values were compared using the Student’s t-test (parametric variables) or the Mann–Whitney U test (non-parametric variables); proportions were compared using the chi-squared test; we considered statistically significant p < 0.05; NS—non-significant.

Table 2. Comparative assessment of SK patients with UTI (group C) versus SK patients without other pathology (group A).

Parameter	Group C (n = 14)	Group A (n = 17)	p
Age, years	58.07 ± 13.61	51.17 ± 9.39	NS
Sex
Male (%)	21.42 (n = 3)	41.17 (n = 7)	NS
Female (%)	78.58 (n = 11)	58.82 (n = 10)	NS
Duration of existence of a SK, years	13.55 ± 12.33	33.23 ± 21.73	0.005
Serum creatinine, mg/dL (day 0)	1.17 ± 0.25	1.01 ± 0.15	NS
Serum creatinine, mg/dL (day 7)	1.16 ± 0.28	1.01 ± 0.15	NS
Urine albumin/creat urine (mg/g) (day 0)	36.29 ± 43.49	17.27 ± 14.88	NS
GFR, ml/min/1.73 m^2 (day 0)	56.78 ± 10.85	71.01 ± 11.31	0.0013
NAG/creat urine (U/g) (day 0)	5.15 ± 6.54	2.89 ± 2.108	NS
Alpha-1-microglobulin urine/creat urine (mg/g) (day 0)	4.96 ± 6.57	2.88 ± 5.57	0.032

Notes: The data are presented as average value ± standard deviation or number (%) of patients. Average values were compared using the Student’s t-test (parametric variables) or the U Mann–Whitney test (non-parametric variables); proportions were compared using the chi-squared test; we considered statistically significant p < 0.05; NS—non-significant.

Table 3. Comparative assessment of SK patients with UTI (group C) on study day 7 versus study day 0.

Parameter	Group under study, day 0 (n = 14)	Group under study, day 7 (n = 14)	p
GFR, ml/min/1.73 m^2	56.78 ± 10.85	57.49 ± 11.73	0.868
NAG/creat urine (U/g)	5.15 ± 6.54	18.99 ± 14.07	0.004
Alpha-1-microglobulin  urine/creat urine (mg/g)	4.96 ± 6.57	20.88 ± 18.84	0.003

Notes: The data are presented as average value ± standard deviations. Average values were compared using the Student’s t paired test. We considered statistically significant p < 0.05.