Figures & data
Figure 1. Plasma 8-isoprostane (a) and NAD(P)H oxidase (b) activity in the renal homogenates from acute renal failure (ARF) and normal rats (control) rats with or without ciglitazone (Cig) pretreatment. Values are mean ± SEM. *p < 0.05 versus control. #p < 0.05 versus ARF.
Figure 2. Production of nitric oxide (a) in 24 hr and expression (b) of endothelial nitric oxide synthase (eNOS) in the renal homogenate from control (control) and acute renal failure rats (ARF) treated with ciglitazone (Cig). Values are mean ± SEM. *p < 0.05 versus control. #p < 0.05 versus ARF.
Figure 3. Protein expression of P47phox (a) and P22phox (b) subunit of NAD(P)H oxidase in the renal homogenate from control (control) and acute renal failure (ARF) rats treated with ciglitazone (Cig). Values are mean ± SEM. *p < 0.05 versus control. #p < 0.05 versus ARF.
Figure 4. Urinary excretion of protein (a), Creatinine (b) and Nitrite (c) in 24 hr in the wild type (+/+) and gp91phox knock-out (+/−) mice before and after induction of acute renal failure. Values are mean ± SEM. *p < 0.05 versus (+/+) control. @p < 0.05 versus (+/+) ARF. #p < 0.05 versus (−/−) control.
Figure 5. Plasma 8-Isoprostane (a) and NAD(P)H oxidase (b) activity in the renal homogenates from wild type (+/+) and gp91phox knockout (+/−) mice before and after induction of acute renal failure. Values are mean ± SEM. *p < 0.05 versus (+/+) control. @p < 0.05 versus (+/+) ARF. #p < 0.05 versus (−/−) control.
Figure 6. PPARγ protein expression (a) and activity (b) in the renal homogenate from wild type (+/+) and gp91phox knockout (+/−) mice before and after induction of acute renal failure. Values are mean ± SEM. *p < 0.05 versus (+/+) control. @p < 0.05 versus (+/+) ARF. #p < 0.05 versus (+/−) control.
