The restoration of kidney mitochondria function by inhibition of angiotensin-II production in rats with acute adriamycin-induced nephrotoxicity

Figures & data

Figure 1. The effect of renin–angiotensin II inhibitors on plasma creatinine kinase levels in rats with nephrotoxicity induced by ADR. TOS: Total oxidant status, Cont: Control group, ADR: Adriamycin group, CAP: Captopril group, AL: Aliskren group, CAP + AL: Captopril plus Aliskren group. a: p < 0.05 versus Cont. All data were expressed as mean ± SEM.

Table 1. The effect of renin–angiotensin II inhibitors on mitochondrial and cytosolic TOS in rats with nephrotoxicity induced by ADR.

Groups	Mitochondria (μmolH2O2 Equiv./L)	Cytosol (μmolH2O2 Equiv./L)
Cont	0.083 ± 0.008	0.19 ± 0.04
ADR	0.16 ± 0.015^a	0.26 ± 0.014^a
CAP	0.1261 ± 0.03	0.11 ± 0.03^b
AL	0.13 ± 0.012	0.17 ± 0.02^b
CAP + AL	0.079 ± 0.043^b	0.87 ± 0.02^b

All data were expressed as mean ± SEM. TOS: Total oxidant status, Cont: Control group, ADR: Adriamycin group, CAP: Captopril group, AL: Aliskren group, CAP + AL: Captopril plus Aliskren group.

^ap < 0.01 versus CONT.

^bp < 0.05 versus ADR.

Table 2. The effect of renin–angiotensin II inhibitors on mitochondrial and cytosolic TAS in rats with nephrotoxicity induced by ADR.

Groups	Mitochondria (mmolTrolox Equiv./L)	Cytosol (mmolTrolox Equiv./L)
Cont	1.5 ± 0.03	1.4 ± 0.1
ADR	1.4 ± 0.07	1.3 ± 0.1
CAP	1.7 ± 0.02^a,b,c	1.2 ± 0.03^d,e,f
AL	1.4 ± 0.07	1.5 ± 0.03
CAP + AL	1.4 ± 0.04	1.5 ± 0.04

All data were expressed as mean ± SEM. TAS: Total antioxidant status, Cont: Control group, ADR: Adriamycin group, CAP: Captopril group, AL: Aliskren group, CAP + AL: Captopril plus Aliskren group.

^ap < 0.01 versus ADR.

^bp < 0.01versus AL.

^cp < 0.01 versus CAP + AL.

^dp < 0.05 versus CONT.

^ep < 0.01 versus AL.

^fp < 0.01 versus CAP + AL.

Figure 2. The effect of renin–angiotensin II inhibitors on mitochondrial membrane potential in rats with nephrotoxicity induced by ADR. MMP: Mitochondrial membrane potential, Cont: Control group, ADR: Adriamycin group, CAP: Captopril group, AL: Aliskren group, CAP + AL: Captopril plus Aliskren group. a: p < 0.05 versus CONT, b: p < 0.001 versus ADR, c: p < 0.01versus CAP + AL. All data were expressed as mean ± SEM.

Figure 3. The effect of renin–angiotensin II inhibitors on ATP level in rats with nephrotoxicity induced by ADR. Cont: Control group, ADR: Adriamycin group, CAP: Captopril group, AL: Aliskren group, CAP + AL: Captopril plus Aliskren group. All data were expressed as mean ± SEM.