Minimal change disease associated with newly diagnosed mantle cell lymphoma

Figures & data

Figure 1. MRI orbits shows an ill-defined hyperdense enhancing nodule in the left intraconal region (arrow).

Figure 2. The light microscopic features of the renal biopsy are normal (A). Electron microscopy of glomeruli showed diffuse effacement of the podocytes (B). There is diffuse but mild thinning of the glomerular basement membranes. No immune-complex deposits are identified. The appearance is in-keeping with minimal change disease.

Table 1. Reported cases of mantle cell lymphoma associated with renal disease.

Case	Age/sex	Type of kidney disease	Creatinine (μmol/L)	Proteinuria (g/day)	Treatment	Outcome	References
1	76/M	MCL infiltration	465	1.8	Chemotherapy, radiotherapy, methylprednisolone, thalidomide	Died 10 months after diagnosis of renal disease	Baldus et al.3
2	75/M	Segmental proliferative GN	573	ND	Short-term HD, cyclophosphamide, PN	Survived 3 years	Rerolle et al.4
3	68/M	Diffuse endocapillary proliferative GN	1043	ND	HD, PN, chlorambucil	Survived 3 years	Da’as et al.2
4	68/M	FSGS	899	18	Short-term HD, cyclophosphamide, plasma exchangeR-CVP for MCL	Survived till time of report (2 years)	Wu et al.5
5	69/M	MCL infiltration	981	1.1	HD, patient opted for no other treatment	Survived 12 months.	Karim et al.6
6	73/M	AIN	483	ND	HD	ND	Karim et al.6
7	69/M	AIN	707	1.3	PN	Renal function returned to normal but died 12 months later with progressive MCL	Colak et al.7
8	52/M	Diffuse proliferative GN	310	3.9	Short-term HD, solumedrol, adrimycin, cyclophosphamide, PN	Renal function returned to normal, survival ND	Davies et al.8
9	59/ND	Membranoproliferative GN	773	6.88	ND	ND	Wong et al.9
10	72/F	MCL infiltration	362	0.2	Short-term HD, PN, vincristine, prednimustine, mitoxantrone	Partial recovery; survived 7 months	Lee et al.10
11	77/M	Crescentic GN	572	1.5	Short-term HD, PN, 5 cycles of CHOP then aracytin	Renal function improved but died of other complications	Lubas et al.11
12	68/M	Membranoproliferative GN	282	ND	HD in short-term, R-Hyper-CVAD	Renal function improved; HD-free but lost to follow-up	Chu et al.12
13	55/F	MCD	100	9.94	PN, CHOP and autologous hemopoietic stem cell transplant	Survived till time of report (24 months)	Current

AIN, acute intersitial nephritis; CHOP, cyclophosphamide, doxorubicin, vincristine and prednisolone; FSGS, focal and segmental glomerulonephritis; GN, glomerulonephritis; HD, haemodialysis; MCD, minimal change disease; MCL, mantle cell lymphoma; ND, not documented; PN, prednisolone; R-CVP, rituximab, cyclophosphamide, vincristine and prednisolone.

Baldus M, Klooker P, Kress S, et al. Primary bilateral renal centrocytic non-Hodgkin’s lymphoma as a cause of renal failure. Nephron. 1996;73:86–90

 PubMedGoogle Scholar

Rerolle JP, Thervet E, Beaufils H, et al. Crescentic glomerulonephritis and centrocytic lymphoma. Nephrol Dial Transplant. 1999;14:1744–1745

 PubMed Web of Science ®Google Scholar

Da’as N, Polliack A, Cohen Y, et al. Kidney involvement and renal manifestations in non-Hodgkin’s lymphoma and lymphocytic leukemia: a retrospective study in 700 patients. Eur J Hematol. 2001;67:158–164

 PubMed Web of Science ®Google Scholar

Wu Q, Jinde K, Yanagi H, et al. Acute interstitial nephritis with polyclonal B cell infiltration and development of mantle cell lymphoma. Intern Med. 2002;41:1158–1162

 PubMed Web of Science ®Google Scholar

Karim M, Hill P, Pillai G, et al. Proliferative glomerulonephritis associated with mantle cell lymphoma – natural history and effect of treatment in 2 cases. Clin Nephrol. 2004;61:422–428

 PubMed Web of Science ®Google Scholar

Colak N, Dede F, Canbakan B, et al. Acute tubulointerstitial nephritis associated with mantle cell lymphoma presented as acute renal failure. Nephrology. 2007;12:107–108

 PubMedGoogle Scholar

Davies J, Healey DA, Wood KM, et al. Acute renal failure due to mantle cell lymphoma – a case report and discussion of the literature. Clin Nephrol. 2007;67:394–396

 PubMedGoogle Scholar

Wong CF, Mohteshamzadeh M, Arsalanizadeh B, et al. Successful treatment of focal segmental glomerulosclerosis in association with mantle cell lymphoma. Ren Fail. 2007;29:363–366

 PubMed Web of Science ®Google Scholar

Lee HJ, Seo JW, Cho HS, et al. Renal involvement of mantle cell lymphoma leading to end stage renal disease. Hemodial Int. 2012;16:104–108

 PubMedGoogle Scholar

Lubas A, Mróz A, Smoszna J, Niemczyk S. Membranoproliferative glomerulonephritis, mantle cell infiltration and acute kidney injury. Int Urol Nephrol. 2013;45:1489–1494

 PubMedGoogle Scholar

Chu JR, Dierksen JE, Glass WF, Aisenberg GM. Association of membranoproliferative glomerulonephritis with mantle cell lymphoma. BMJ Case Rep. 2013;2013. doi: 10.1136/bcr-2013-009730

 Google Scholar