Experimental comparison of protective characteristics of enalapril and trimetazidine in diabetic nephropathy

Figures & data

Figure 1. Comparison between the groups in terms of immunoexpression percentage.

Table 1. Comparison between the groups according to the level of blood sugar, glomerular area (% of control), immunoexpression fibronectin percentage, immunoexpression i-NOS percentage, proteinuria (mg/dL), blood glucose (mg/dL).

	Control	Diabetes	Diabetes and enalapril	Diabetes and trimetazidine
Glomerular area (% of control)	100^a	165 ± 10.24	123 ± 6.32^a	135 ± 3.56^a
Immunoexpression fibronectin percent (%)	10.2 ± 2.3^a	78.6 ± 8.2	35.1 ± 6.8^a	23.8 ± 3.6^a
Immunoexpression i-NOS percent (%)	8.6 ± 1.2^a	65.2 ± 10.3	32.5 ± 4.5^a	12.4 ± 4.8^a
Proteinuria (mg/dL)	0.18 ± 0.05^a	2.56 ± 0.2	0.56 ± 0.2^a	0.45 ± 0.1^a
Blood glucose (mg/dL)	95.6 ± 8.5^a	423.1 ± 15.6	418.3 ± 12.3	435.2 ± 10.2

Note: ^aStatistically significantly lower (p < 0.05).

Figure 2. H & E staining (×100 magnification): (a) control group (non-diabetes group), (b) diabetes group, (c) diabetes and enalapril, (d) diabetes and trimetazidine.

Figure 3. Fibronectin immunostaining (×100 magnification); (a) control group (non-diabetes group), (b) diabetes group, (c) diabetes and enalapril, (d) diabetes and trimetazidine.

Figure 4. NOS-2 (i-NOS) immunostaining (×100 magnification): (a) control group (non-diabetes group), (b) diabetes group, (c) diabetes and enalapril, (d) diabetes and trimetazidine.

Figure 5. H & E staining (×40 magnification); (a) control group (non-diabetes group), (b) diabetes group, (c) diabetes and enalapril, (d) diabetes and trimetazidine.

Table 2. Comparison between the groups according to the mean glomerulosclerosis, immunoexpression fibronectin, immunoexpression i-NOS score.

	Control	Diabetes	Diabetes and enalapril	Diabetes and trimetazidine
Glomerulosclerosis score	0.12 ± 0.35^a	3.75 ± 0.46	2.12 ± 0.83^a	2.25 ± 0.46^a
Immunoexpression fibronectin score	0.25 ± 0.46^a	3.5 ± 0.75	1.87 ± 0.35^a	1.25 ± 0.46^a
Immunoexpression i-NOS score	0.12 ± 0.35^a	3.62 ± 0.51	1.87 ± 0.35^a	1 ± 0.53^a

Note: Standard deviation; ±^aStatistically significantly lower (p < 0.05).