Figures & data
Figure 1. Effect of uPA on blood glucose, serum creatinine, urine protein, and kidney weight of rats in control, diabetic rats (DM), and diabetic rats treated with uPA (DM + uPA) group. *p < 0.01, compared with control group. Δp < 0.01, compared with diabetic rat group.
Figure 2. Effect of uPA on AG, AM, and VG in rat renal tissues of control, diabetic rats (DM), and diabetic rats treated with uPA (DM + uPA) group. AG, glomerular mean area. AM, mesangial area. VG, glomerular mean volume. All the data are expressed as mean ± standard deviation. *p < 0.01, compared with control group. Δp < 0.01, compared with diabetic rat groups.
Figure 3. Pathologic change of rat renal tissues of the three groups (PASM × 400). (A) Control group. (B) diabetic (DM) group. (C) Diabetes treated with uPA (DM + uPA) group. AG, glomerular mean area. AM, mesangial area. VG, glomerular mean volume.
Figure 4. Glomerular uPAR expression in rats of the three groups (IHC × 400). (A) Control group. (B) Diabetic (DM) group. (C) Diabetes treated with uPA (DM + uPA) group. ☆p < 0.01, compared with control group. #p < 0.01, compared with diabetic rat group.
Figure 5. Glomerular PAI-1 expression in rats of the three groups (IHC × 480). (A) Control group. (B) Diabetic (DM) group. (C) Diabetes treated with uPA (DM + uPA) group. ☆p < 0.01, compared with control group. #p < 0.01, compared with diabetic rat group.
Figure 6. Glomerular collagen IV expression in rats of the three groups (IHC × 480). (A) Control group. (B) Diabetic (DM) group. (C) Diabetes treated with uPA (DM + uPA) group. ☆p < 0.01, compared with control group. #p < 0.01, compared with diabetic rat group.
