The effect of biocompatible peritoneal dialysis solutions on neutrophil to lymphocyte ratio

Figures & data

Table 1. Demographic and clinic features of the study groups.

	Patients with Biocompatible Solutions (n: 71)	Patients with Standard Solutions (n: 49)	p Value
Age (years)	49.5 ± 14.1	48.4 ± 13.2	0.66
Female/Male	36/35	24/25	0.85
BMI (kg/m^2)	27.3 ± 5.8	26.4 ± 4.8	0.36
Office SBP (mmHg)	133.7 ± 19.6	138.9 ± 23.7	0.37
Office DBP (mmHg)	84.3 ± 9.8	84.8 ± 14.3	0.86
Primary etiology of CKD			0.21
Diabetic nephropathy	17 (23.9%)	13 (26.5%)
Hypertensive nephrosclerosis	19 (26.8%)	7 (14.3%)
Chronic glomerulonephritis	11 (15.5%)	7 (14.3%)
Polycystic kidneys	2 (2.8%)	2 (4.1%)
Reflux nephropathy	4 (5.6%)	–
Others or unknown	18 (25.4%)	20 (40.8%)
PD characteristics
Time on PD (months)	59.8 ± 39.0	52.4 ± 28.7	0.23
Peritoneal Kt/V per week (units)	2.73 ± 1.23	2.63 ± 0.77	0.90
Daily UF volume (ml)	574 ± 73	540 ± 78	0.63
Daily urine volume (ml)	721 ± 86	502 ± 73	0.06

Abbreviations; BMI: Body mass index, SBP: Systolic blood pressure, DBP: Diastolic blood pressure, CKD: Chronic kidney disease, PD: peritoneal dialysis, Kt/V: Urea clearance index used to represent weekly dialysis dose; where K is the clearance of urea, t is the dialysis time and V is the volume of distribution of urea, UF: Ultrafiltration. Values expressed with a plus/minus sign are the mean ± standard deviation. All other values are the number (percentage) of patients.

Table 2. Laboratory findings and peritonitis indices of the study groups (mean ± SD).

	Patients with Biocompatible Solutions (n: 71)	Patients with Standard Solutions (n: 49)	p Value
Creatinine (mg/dl)	8.3 ± 2.9	8.8 ± 2.9	0.39
Albumin (g/dl)	3.7 ± 0.4	3.6 ± 0.5	0.15
Calcium (mg/dl)	8.9 ± 0.9	8.7 ± 0.8	0.52
Phosphorus (mg/dl)	4.9 ± 1.3	4.6 ± 1.3	0.13
Parathormone (pg/ml)	535 ± 464	595 ± 421	0.48
Ferritin (mg/dl)	588 ± 325	540 ± 362	0.45
Total cholesterol (mg/dl)	200 ± 44	195 ± 49	0.55
Triglyceride (mg/dl)	207 ± 110	204 ± 142	0.92
Hemoglobin (g/dl)	11.0 ± 1.5	10.6 ± 1.8	0.11
WBC count (cell/mm^3)	7895 ± 1910	7520 ± 1788	0.28
Neutrophil count (cell/mm^3)	5416 ± 1583	5026 ± 1504	0.18
Lymphocyte count (cell/mm^3)	1547 ± 444	1640 ± 493	0.28
Platelet count (×10^3 cell/mm^3)	251 ± 75	240 ± 83	0.52
MPV(fL)	7.98 ± 0.97	7.92 ± 1.08	0.58
N/L ratio	3.75 ± 1.50	3.27 ± 1.34	0.04
P/L ratio	176 ± 79	157 ± 69	0.18
ESR (mm/h)	51.9 ± 32.7	44.1 ± 25.7	0.37
hs-CRP (mg/dl)	3.2 ± 2.5	1.8 ± 2.0	<0.01
Peritonitis rates (episodes per patient year)	0.23 ± 0.35	0.27 ± 0.32	0.36
Time to first peritonitis episode (months)	32.8 ± 35.8	21.5 ± 26.9	0.16

Abbreviations; WBC: White blood cell, MPV: Mean platelet volume, N/L ratio: neutrophil-to-lymphocyte ratio, P/L ratio: platelet-to-lymphocyte ratio, ESR: Erythrocyte sedimentation rate, hs-CRP: High sensitive C-reactive protein. Values expressed with a plus/minus sign are the mean ± standard deviation.