The relationship of Prohepcidin levels with anemia and inflammatory markers in non-diabetic uremic patients: a controlled study

Figures & data

Figure 1. The distribution of hepcidin levels of the groups. HD: hemodialysis, PD: peritoneal dialysis.

Table 1. The demographic and clinical data of the groups.

	Predialysis Group No = 21 (mean ± SD)	HD Group No = 20 (mean ± SD)	PD Group No = 21(mean ± SD)	Control Group No = 17 (mean ± SD)	p Value
Female/male	12/9	8/12	14/7	9/8	0.388
Age (year)	54.9 ± 14.3	49.8 ± 12.0	47.7 ± 12.1	54.0 ± 7.2	0.196
BMI (kg/m^2)	26.6 ± 3.5	23.6 ± 4.1	28.4 ± 7.7	28.0 ± 4.6	0.017
Glucose (mg/dl)	105 ± 24	99 ± 25	110 ± 24	100 ± 9	0.089
Urea (mg/dl)	110 ± 36	111 ± 34	97 ± 19	31.7 ± 10	<0.001
Creatinine (mg/dl)	3.53 ± 1.39	7.43 ± 2.05	7.89 ± 2.74	0.77 ± 0.13	<0.001
Kt/V	–	1.5 ± 0.2	2.01 ± 0.25	–
GFR (ml/dk)	20.1 ± 7.6	–	–	104 ± 17	–
Total protein (g/dl)	6.7 ± 0.7	7.1 ± 0.7	6.6 ± 0.72	7.1 ± 0.8	0.081
Albumin (g/dl)	3.8 ± 0.5	4.1 ± 0.4	3.6 ± 0.3	4.1 ± 0.3	<0.001
Calcium (mg/dl)	8.9 ± 0.8	9.1 ± 0.9	9.0 ± 0.6	9.7 ± 0.5	0.002
Phosphorus (mg/dl)	4.5 ± 0.9	4.1 ± 1.1	5.2 ± 1.4	3.5 ± 0.5	<0.001
Cholesterol (mg/dl)	198 ± 57	185 ± 47	196 ± 47	208 ± 37	0.441
Triglyceride (mg/dl)	142 ± 65	211 ± 134	179 ± 117	116 ± 59	0.004
Uric acid (mg/dl)	7.7 ± 1.6	5.2 ± 1.5	5.7 ± 1.4	5.1 ± 1.3	<0.001
hsCRP (mg/l)	1.07 ± 0.85	0.88 ± 0.64	1.09 ± 1.38	0.52 ± 0.62	0.094
Fibrinogen (mg/dl)	380 ± 80	436 ± 116	582 ± 108	344 ± 107	<0.001
IL-6 (pg/ml)	16.0 ± 19.3	40.2 ± 67.0	48.5 ± 109.2	10.6 ± 14.9	0.033
Prohepcidin (ng/ml)	119.6 ± 45.1	140.2 ± 41.8	148.2 ± 35.0	93.8 ± 21.9	<0.001

Note: HD: hemodialysis, PD: peritoneal dialysis, hsCRP: high sensitive C-reactive protein, IL-6: interleukin-6, BMI: body mass index, GFR: glomerular filtration rate.

Table 2. Hematological and iron-related parameters.

	Predialysis Group (mean ± SD)	HD Group (mean ± SD)	PD Group (mean ± SD)	Control Group (mean ± SD)	p Value
Leukocyte (mm^3)	8238 ± 2385	6743 ± 1999	7358 ± 1553	6935 ± 2112	0.159
Hemoglobin (g/dl)	11.2 ± 1.9	11.7 ± 1.2	10.7 ± 1.7	13.5 ± 1.1	<0.001
Hematocrit (%)	33.1 ± 5.41	35.3 ± 3.5	32.1 ± 5.2	40.5 ± 3.3	<0.001
Iron (mcg/dL)	54.4 ± 24.9	58.6 ± 19.5	73.1 ± 32.1	81 ± 41	0.108
TIBC (mcg/dL)	282 ± 72	247 ± 57	255 ± 62	352 ± 70	<0.001
TSAT (%)	20.5 ± 12.1	24.7 ± 9.7	29.4 ± 14.8	24.0 ± 13.8	0.052
Ferritin (ng/ml)	182 ± 156	769 ± 389	269 ± 135	82.7 ± 57.5	<0.001

Note: HD: hemodialysis, PD: peritoneal dialysis, TIBC: total iron binding capacity, TSAT: transferrin saturation.

Figure 2. Relationship of prohepcidin with total iron binding capacity.