Normal mesenteric lymph ameliorates acute kidney injury following lipopolysaccharide challenge in mice

Figures & data

Figure 1. Effect of NML on renal function indices after LPS administration in mice (mean±SD, n = 6). Note: *p < 0.05 versus the sham group; #p < 0.05 versus the LPS group.

Figure 2. Effect of NML on renal morphological change in mice (HE staining). Note: A–B: Sham group; C–D: lipopolysaccharide (LPS) group; E–F: LPS + NML group.

Table 1. Effects of NML on the phosphorylation levels of p38 MAPK, ERK 1/2, and c-Jun NH2-terminal protein kinase (JNK) in kidney after LPS administration in mice (ng/mg protein, mean±SD, n = 6).

Group	p-p38 MAPK	p-ERK 1/2	p-JNK
Sham	1.01 ± 0.23	2.16 ± 0.48	2.97 ± 0.74
LPS	1.02 ± 0.21	1.98 ± 0.51	2.93 ± 0.68
LPS+NML	0.89 ± 0.13	1.75 ± 0.25	2.27 ± 0.38

Figure 3. Effects of NML on the levels of LBP and CD14 in kidney after LPS administration in mice (mean ± SD, n = 6). Note: *p < 0.05 versus the sham group; #p < 0.05 versus the LPS group.

Figure 4. Effects of NML on the levels of TNF-α and IL-6 in kidney after LPS administration in mice (mean ± SD, n = 6). Note: *p < 0.05 versus the sham group; #p < 0.05 versus the LPS group.