Urine neutrophil gelatinase-associated lipocalin in septic patients with and without acute kidney injury

Figures & data

Table 1. Characteristics of patients by septic AKI status.

	Septic AKI (n = 58)	Septic non-AKI (n = 68)	p Values
Demographic characteristics
Age, years (IQR)	64 (47–73)	51 (46–59)	0.002
Male gender, n (%)	39 (67%)	47 (69%)	0.476
Admission uNGAL (ng/mL, IQR)	337 (196–479)	121 (79–185)	< 0.0001
Peak uNGAL (ng/mL, IQR)	457 (379–621)	154 (127–213)	< 0.0001
Renal function
Peak blood urea nitrogen (mmol/L, IQR)	29.7 (19.6–33.4)	4.7 (2.9–8.1)	< 0.0001
Peak serum creatinine (mmol/L, IQR)	446 (301–756)	76 (43–102)	< 0.0001
Peak uric acid (mmol/L, IQR)	456 (372–596)	397 (197–529)	0.093
Clinical records
Proteinuria, n (%)	54 (93%)	7 (10%)	< 0.0001
Hematuria, n (%)	49 (84%)	5 (7%)	< 0.0001
Dialysis required, n (%)	23 (40%)	0 (0%)	< 0.0001
Length of hospital stay (days)	36 (21–49)	12 (9–15)	< 0.0001
ICU mortality, n (%)	41 (71%)	18 (26%)	< 0.0001

Figure 1. Correlations of peak uNGAL with the levels of peak BUN (A), peak SCr (B) and the lengths of hospital stay (C). The r denotes the Spearman correlation coefficient, and the line denotes the linear regression for each comparison.

Figure 2. Receiver-operating-characteristic (ROC) curves for uNGAL to predict the development of septic AKI.

Table 2. Multivariable logistic regression for the prediction of septic AKI combining peak uNGAL with other variables.

	Adjusted odds ratio	95% CI	p
Age (per year)	1.12	1.06–1.18	0.082
Gender	0.87	0.23–4.97	0.912
Presence of hematuria	7.63	3.21–35.67	<0.001
Presence of proteinuria	1.07	0.31–6.91	0.766
Peak uNGAL	32.12	6.21–90.37	<0.0001

Figure 3. Peak uNGAL associated with hemodialysis. Peak uNGAL correlated with the number of hemodialysis sessions each patient received during hospitalization (A). Shown are ROC curves for peak uNGAL in predicting the need of hemodialysis (B).