Thyroid hormone replacement for nephrotic syndrome patients with euthyroid sick syndrome: a meta-analysis

Figures & data

Figure 1. Selection of the studies included in the meta-analysis.

Table 1. Characteristics of included studies.

Studies	Design	Jadad scores	Follow-up (months)	Differences in therapies	Number of participants	Results
Duan et al., 200821	Randomized, double-blind, parallelled	4	12	Experimental group: levothyroxine 50 µg/(kg d); Controls: placebo	40 in experimental group, 38 in controls	Experimental group 34 CR, 3 PR, 3 invalid; Controls 26 CR, 4 PR, 8 invalid
Hu et al., 200522	Randomized, double-blind, parallelled	4	12	Experimental group: levothyroxine 50 µg/(kg d); Controls: placebo	26 in experimental group, 24 in controls	Experimental group 22 CR, 2 PR, 2 invalid; Controls 14 CR, 3 PR, 7 invalid
Li et al., 200523	Randomized, double-blind, parallelled	4	3	Experimental group: levothyroxine 50 µg/(kg d); Controls: placebo	25 in experimental group, 23 in controls	Experimental group 16 CR, 6 PR, 3 invalid; Controls 11 CR, 3 PR, 9 invalid
Nie et al., 200824	Randomized, double-blind, parallelled	3	6	Experimental group: levothyroxine 25–50 µg/(kg d); Controls: placebo	36 in experimental group, 30 in controls	Experimental group 30 CR, 3 PR, 3 invalid; Controls 15 CR, 5 PR, 10 invalid
Zhang et al., 200425	Randomized, double-blind, parallelled	4	6	Experimental group: thyroxine 20–40 mg/(kg d); Controls: placebo	26 in experimental group, 24 in controls	Experimental group 16 CR, 8 PR, 2 invalid; Controls 11 CR, 7 PR, 6 invalid
Xie, 200920	Randomized, double-blind, parallelled	3	12	Experimental group: levothyroxine 20 µg/(kg d); Controls: placebo	20 in experimental group, 17 in controls	Experimental group 16 CR, 2 PR, 2 invalid; Controls 7 CR, 3 PR, 7 invalid

Notes: CR: completely remission and PR: partially remission.

Figure 2. (A) The meta-analysis of completely remission rate of six studies (fixed effects model). (B) The funnel plots of six studies in analysis of completely remission rate (fixed effects model).

Figure 3. (A) The meta-analysis of rate of total response rate of six studies (fixed effects model). (B) The funnel plots of six studies in analysis of total response rate (fixed effects model).

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