Effects of dexpanthenol and N-acetylcysteine pretreatment in rats before renal ischemia/reperfusion injury

Figures & data

Figure 1. Post-operative biochemical values of groups. *Post-operative BUN values of group 2 were significantly higher than other groups; #post-operative NGAL values of group 2 were significantly higher than other groups; +post-operative creatinine values of group 2 were significantly higher than other groups; ¥post-operative TNF-α values of group 2 were significantly higher than other groups.

Figure 2. Histopathological examination under light microscopy. (A) Normal glomerul and tubulus Sham group. (B) Intersitisial inflamation I/R + NAC group. (C) Focal necrosis in glomerul I/R Group. (D) Proteinaceous cast in tubuli I/R Group. (E) Tubuler dilatation I/R + DXP group. (F) Tubuler necrosis I/R group. (G) Congestion I/R + NAC group. (H) Interstitial edema I/R + DXP group. (I) Bowman's capsule dilatation I/R + DXP group.

Table 1. Histopathological scoring of groups.

	Glomerular focal necrosis	Bowman’s space dilatation	Tubular dilatation	Acute tubular necrosis	Interstitial edema	Interstitial inflammation	Tubular proteinaceous accumulation	Congestion
Group 1 Sham	0.00	0.00	0.00	0.00	0.00	0.63 ± 0.52	0.00	0.75 ± 0.46
Group 2 IR	0.88 ± 0.64	0.38 ± 0.52	2.00 ± 0.76	2.25 ± 0.89	1.38 ± 0.52	1.00 ± 0.76	2.38 ± 0.92	1.88 ± 0.84
Group 3 IR + NAC	0.13 ± 0.35	0.63 ± 0.52	0.75 ± 0.46	0.50 ± 0.76	0.38 ± 0.52 *	0.75 ± 0.46*	0.88 ± 1.12	1.25 ± 0.46
Group 4 IR + DXP	0.63 ± 0.74	0.75 ± 0.46	1.38 ± 0.74	1.38 ± 1.3	1.13 ± 0.35*	1.50 ± 0.54*	1.50 ± 1.2	1.25 ± 0.46
Group 5 IR + NAC + DXP	0.00	0.00	0.38 ± 0.52	0.13 ± 0.35	0.25 ± 0.46	0.25 ± 0.46	0.25 ± 0.46	0.75 ± 0.46

Mean ± SD (n = 8). Grades of scoring: no change (0), mild (1), moderate (2), severe (3). *p < 0.05 renal IR + NAC versus renal IR + DXP.