Renal failure due to granulomatous interstitial nephritis in native and allograft renal biopsies: experience from a tertiary care hospital

Figures & data

Table 1. Demographic, clinical and pathological details of patients with granulomatous interstitial nephritis.

Age	Sex	S.Creatinine mg/dL	Diagnosis/confirmatory test	Interstitial fibrosis/tubular atrophy	Treatment	Follow-up	Outcome creatinine mg/dL
32	f	3.89	Tuberculosis/AFB positive mediastinal  lymph node	Mild	Anti-tubercular	9 months	2.5
57	m	6.70	Drug	Mild	Steroids	5 months	2.3
30^a	m	2.49	Klebsiella/urine Culture+	Mild	Antibiotics	7 months	1.4
35^a	M	1.90	Tuberculosis/QuantiFERON-TB Gold+	Moderate	Anti-tubercular	8 months	Transplant
22	m	15.2	Tuberculosis/QuantiFERON-TB Gold+	Mild	Anti-tubercular	–	No follow-up
37	M	11.2	Tuberculosis/QuantiFERON-TB Gold+	Moderate	Anti-tubercular	18 months	Dialysis dependent
12	F	7.30	Tuberculosis/QuantiFERON-TB Gold+	Mild	Anti-tubercular	18 months	1.3
21	F	7.60	Tuberculosis/QuantiFERON-TB Gold++	Moderate	Anti-tubercular	14 months	Dialysis dependent
34	F	4.20	Tuberculosis/QuantiFERON-TB Gold+	Mild	Anti-tubercular	30 months	2.6
27	f	5.45	Tuberculosis/QuantiFERON-TB Gold+	Mild	Anti-tubercular	28 months	2.7
45	M	4.10	Drug	Mild	Steroids	12 months	1.4
20	m	5.40	Idiopathic	Mild	Steroids	9 months	1.3
29	m	4.80	Idiopathic	Mild	Steroids	11 months	1.4
39	f	9.70	Tuberculosis/QuantiFERON-TB gold+	Mild	Anti-tubercular	–	No follow-up
35	m	7.70	Pauci-immune GN	Mild	Steroids, cyclophosphamide	–	No follow-up
68	m	2.40	Pauci-immune GN	Mild	Steroids, cyclophosphamide	–	No follow-up

Notes: S.creatinine, serum creatinine; Pauci-immune GN, pauci-immune glomerulonephritis.

^aRenal allograft recipients.

Figure 1. Renal biopsy showing interstitial epithelioid cell granuloma, Langhan’s giant cell and focal necrosis along with atrophic tubules (Hematoxylin and eosin, ×200).