Efficacy of adefovir dipivoxil combined with a corticosteroid in 38 cases of nephrotic syndrome induced by hepatitis B virus-associated glomerulonephritis

Figures & data

Table 1. Efficacy analysis of different histopathological types.

Histopathological type	Cases	Complete remission	Partial remission	No remission	Effective rate (%)
MN	19	5	8	6	68.4
MPGN	11	4	4	3	72.7
MsPGN	8	2	5	1	87.5
Total	38	11	17	10	73.7

Table 2. Laboratory examination of 38 patients with HBV-GN before and after treatment.

Time	24 hours urinary protein quantity (g)	Serum albumin (g/L)	Triglyceride (mmol/L)	Cholesterin (mmol/L)	Blood urea nitrogen (mmol/L)	Serum creatinine (µmol/L)	Alanine aminotransferase (U/L)
Pretherapy	5.53 ± 3.5	28.12 ± 5.45	3.08 ± 1.34	7.47 ± 2.16	7.45 ± 1.38	135.06 ± 74.1	64.35 ± 20.16
8th week	3.12 ± 1.24*	32.01 ± 4.62*	2.76 ± 1.18*	6.24 ± 1.75*	6.79 ± 1.02	105.46 ± 38.5	63.16 ± 15.98
12th week	2.87 ± 1.45*	34.25 ± 3.19*	2.19 ± 1.08*	5.69 ± 1.44*	6.70 ± 1.05	94.33 ± 34.1	62.05 ± 14.79
24th week	1.98 ± 1.12*	38.04 ± 2.36*	2.11 ± 0.83*	5.54 ± 1.35*	6.67 ± 1.13	87.34 ± 21.4	59.04 ± 15.11
36th week	1.64 ± 0.83*	38.36 ± 2.51*	2.02 ± 0.76*	5.25 ± 1.04*	6.53 ± 1.24	85.07 ± 20.6	49.16 ± 7.35

Notes: *Indicates a statistically significant p < 0.05.