Association of malnutrition-inflammation score, dialysis-malnutrition score and serum albumin with novel risk factors for cardiovascular diseases in hemodialysis patients

Figures & data

Table 1. Characteristics of the HD patients.

Characteristics	All patients (n = 291)
Age (years)
18–40	45 (15.5%)
41–60	99 (34%)
>60	147 (50.5%)
Sex
Men	164 (56%)
Women	127 (44%)
Dialysis vintage (years)
≤1	60 (21%)
1–5	149 (51%)
5–10	61 (21%)
>10	21 (7%)
Dialysis adequacy (Kt/V)
<1.2	113 (46%)
≥1.2	133 (54%)
Serum creatinine (mg/dL)	9 ± 0.2
Serum urea (mg/dL)	123 ± 1.7

Note: Serum creatinine and urea are presented as mean ± standard error (SE).

Table 2. Correlations of PEW indicators with novel risk factors for CVD in the HD patients.

Parameters	MIS	DMS	Serum albumin
hs-CRP	r = 0.25 (p < 0.01)	r = 0.25 (p < 0.01)	r = −0.32 (p < 0.01)
sICAM-1	r = 0.25 (p < 0.01)	r = 0.23 (p < 0.01)	r = −0.16 (p < 0.01)
sVCAM-1	NS	NS	NS
sE-selectin	NS	NS	NS
MDA	NS	NS	NS
NO	NS	NS	NS
Endothelin-1	NS	NS	NS
Lp (a)	NS	NS	NS

Note: NS: nonsignificant.

Table 3. Serum concentrations of novel risk factors for CVD in the HD patients based on various PEW indicators.

	MIS		DMS		Serum albumin
Parameters	Normal	PEW	Normal	PEW	Normal	Low
hs-CRP (mg/L)	4.7 ± 0.3	6.2 ± 0.2^a	4.5 ± 0.3	6.2 ± 0.2^a	5 ± 0.2	7 ± 0.4^b
sICAM-1 (ng/mL)	614 ± 19	690 ± 21^b	597 ± 19	691 ± 20^b	643 ± 15	721 ± 42^c
sVCAM-1 (ng/mL)	762 ± 35	818 ± 35	764 ± 39	810 ± 32	777 ± 26	874 ± 72
sE-selectin (ng/mL)	27 ± 1	24 ± 1	27 ± 1.5	24 ± 1	25 ± 1	25 ± 4
MDA (µmol/L)	5.7 ± 0.1	5.9 ± 0.1	5.7 ± 0.1	5.8 ± 0.1	5.8 ± 0.1	5.7 ± 0.2
NO (µmol/L)	44 ± 1	41.5 ± 1	43.5 ± 1	42 ± 1	42 ± 0.6	46 ± 1.8
Endothelin-1 (pg/mL)	27.5 ± 2	27 ± 2	26 ± 2	28 ± 2	27 ± 2	32 ± 4.5
Lp (a) (mg/dL)	34 ± 2	31 ± 2	35 ± 3	30 ± 2	32 ± 2	35 ± 4

Notes: All values are presented as mean ± SE.

^ap < 0.001 versus normal.

^bp < 0.01 versus normal.

^cp = 0.05 versus normal.