Single nucleotide polymorphisms in the D-loop region of mitochondrial DNA is associated with the kidney survival time in chronic kidney disease patients

Figures & data

Table 1. Baseline characteristics of the CKD participants.

Variables	All participants
Number of participants	119
Male (%)	56.3
Female (%)	43.7
Age (years)	55.6 ± 14.2
Current smoking (%)	32.7
Yes	32.7
No	67.3
BMI (kg/m^2)	21.8 ± 2.7
Hypertension (%)	68.9
Systolic BP (mmHg)	156.3 ± 24.8
Diastolic BP (mmHg)	87.5 ± 12.6
MAP(mmHg)	112.6 ± 14.7
Etiologies of CKD
Membranous nephrology (%)	50.4
Non-membranous nephrology (%)	49.6
eGFR (mL/min/1.73 m^2)	81.2 ± 12.4
eGFR < 60 (mL/min/1.73 m^2, %)	79.8

Note: BMI, body mass index; MAP, mean arterial pressure; BP, blood pressure.

Table 2. Univariate analysis of clinical characteristics associated with the kidney survival time in chronic kidney disease patients.

Characteristics	No. cases	5 years survival rate of kidney(%)	χ^2	p Value
Age (years)			0.044	0.834
≤65	69	26.1
>65	33	24.2
Gender			5.935	0.015
Male	54	16.7
Female	48	35.4
Smoking			4.620	0.032
Yes	42	14.3
No	60	33.3
BMI (kg/m^2)			1.117	0.291
<25	79	30.4
≥25	23	8.7
MAP (mmHg)			0.013	0.909
≤105	38	28.9
>105	64	23.4
Etiologies of CKD			1.115	0.291
Membranous nephrology	56	23.2
Non-membranous nephrology	46	28.3
eGFR (mL/min/1.73 m^2)			32.370	<0.001
<60	81	12.3
≥60	21	76.2

Note: BMI, body mass index; MAP, mean arterial pressure.

Figure 1. Survival curve of kidney according to the nucleotide at position 146 in D-loop of the chronic kidney disease patients.

Table 3. Multivariate analysis of prognostic factors associated with the kidney survival time in chronic kidney disease patients by the Cox proportional hazards model.

Factors	Relative risk	95% C.I.	p Value
Gender	0.358	0.165–0.776	0.009
Smoking	1.970	0.919–4.225	0.041
eGFR	0.091	0.035–0.234	<0.001
146T/C	2.762	1.599–4.770	<0.001

Table 4. The relationship of clinical characteristics with the frequency of allele 146.

Characteristics	146T	146C	χ^2	p Value
Age (years)			2.606	0.106
≤65	56	13
>65	22	11
Gender			0.366	0.545
Male	40	14
Female	38	10
Smoking			0.281	0.596
Yes	31	11
No	47	13
BMI (kg/m^2)			0.622	0.430
<25	59	20
≥25	19	4
MAP (mmHg)			3.840	0.051
≤105	25	13
>105	53	11
Etiologies of CKD			1.373	0.241
Membranous nephrology	38	18
Non-membranous nephrology	36	10
eGFR (mL/min/1.73 m^2)			1.256	0.262
<60	60	21
≥60	18	3