Association of AGT M235T gene polymorphism with HSP/HSPN risk

Figures & data

Figure 1. Flow chart of study selection.

Table 1. Characteristics of studies evaluating the effects of AGT M235T gene polymorphism on HSP/HSPN risk.

		Case				Control				M allele (%)		HWE
Author, year	Ethnicity	MM	MT	TT	Total	MM	MT	TT	Total	Case	Control	P
HSP/Healthy
Ozkaya et al., 2006	Asian	37	60	17	114	86	65	13	164	58.9	72.1	0.989
Wu et al., 2009	Asian	13	84	40	137	5	54	2	61	40.1	52.5	0.464
Liu et al., 2010	Asian	104	35	2	141	141	69	8	218	86.2	80.5	0.675
An et al., 2012	Asian	23	58	64	145	41	83	48	172	35.9	47.9	0.909
Nalbantoglu et al., 2013	Asian	37	59	43	139	18	50	19	87	47.8	49.4	0.378
HSPN/HSP without nephropathy
Ozkaya et al., 2006	Asian	11	22	11	44	26	38	6	70	70.7	62.9	0.313
Wu et al., 2009	Asian	12	65	30	107	1	19	10	30	41.6	35	0.099
Liu et al., 2010	Asian	42	17	2	61	62	18	0	80	86.2	80.5	0.675
An et al., 2012	Asian	8	19	31	58	15	39	33	87	30.2	39.6	0.839
Nalbantoglu et al., 2013	Asian	22	24	18	64	15	35	25	75	51.1	48.9	0.911

HWE: Hardy-Weinberg equilibrium, AGT: angiotensinogen, HSP: Henoch–Schönlein purpura, HSPN: Henoch–Schönlein purpura nephritis.

Figure 2. Association between M allele and HSP risk.

Figure 3. Association between TT genotype and HSP risk.

Table 2. Meta-analysis of the association of AGT M235T gene polymorphism with HSP/HSPN risk.

			Q test
Study	Ethnicity	Studies	p-Value	Model selected	OR (95% CI)	p-Value
HSP/Healthy
M versus T	Overall	5	0.255	Random	0.884 (0.761–1.026)	0.104
	Adult	1	–	Random	0.748 (0.559–1.000)	0.050
	Children	4	0.311	Random	0.924 (0.790–1.080)	0.321
MM versus (MT + TT)	Overall	5	0.128	Random	0.904 (0.656–1.245)	0.535
	Adult	1	–	Random	0.665 (0.381–1.161)	0.151
	Children	4	0.134	Random	0.974 (0.675–1.404)	0.888
TT versus (MT + MM)	Overall	5	0.064	Random	1.674 (0.983–2.849)	0.058
	Adult	1	–	Random	1.582 (1.024–2.443)	0.039
	Children	4	0.031	Random	1.741 (0.747–4.061)	0.199
HSPN/HSP without nephropathy
M versus T	Overall	5	0.446	Random	0.952 (0.785–1.155)	0.619
	Adult	1	–	Random	0.761 (0.476–1.217)	0.254
	Children	4	0.447	Random	0.997 (0.807–1.231)	0.975
MM versus (MT + TT)	Overall	5	0.313	Random	1.005 (0.682–1.481)	0.980
	Adult	1	–	Random	0.800 (0.319–2.008)	0.635
	Children	4	0.212	Random	1.069 (0.653–1.749)	0.791
TT versus (MT + MM)	Overall	5	0.211	Random	1.265 (0.785–2.037)	0.334
	Adult	1	–	Random	1.409 (0.779–2.548)	0.256
	Children	4	0.138	Random	1.272 (0.628–2.573)	0.504

OR: odds ratio, CI: confidence interval, AGT: angiotensinogen, HSP: Henoch–Schönlein purpura, HSPN: Henoch–Schönlein purpura nephritis.

Figure 4. Publication bias for the analysis of association of AGT M235T gene polymorphism with HSP risk.