Comparison of insulin resistance in the various stages of chronic kidney disease and inflammation

Figures & data

Table 1. Demographic features and anthropometric values of the groups.

Values	Control group	Predialysis patient group	Dialysis patient group	p
Age	41.18 ± 10.97	47.79 ± 13.66	47.88 ± 17.59	0.101
Gender
Male	12 (36.40%)	14 (48.30%)	37 (51.40%)
Female	21 (63.60%)	15 (51.70%)	35 (48.60%)	0.354
Height	165.76 ± 7.55	166.24 ± 7.88	163.90 ± 8.60	0.336
Weight	62.61 ± 8.28	59.00 ± 11.46	61.56 ± 10.44	0.359
Body mass  index	22.68 ± 1.43	21.34 ± 3.77	22.89 ± 3.31	0.07

Table 2. Comparison of insulin resistance and the risk factors for inflammation and cardiovascular disease between the groups.

Variables	Control group	Predialysis patient group	Dialysis patient group	p
Insulin*	3.36 ± 2.14	7.54 ± 10	7.78 ± 8.05	0.019
C-peptide**	1.68 ± 0.56	4.04 ± 2.6	7.52 ± 4.22	0.0001
HOMA-IR***	0.73 ± 0.48	1.70 ± 2.19	1.78 ± 1.87	0.014
Albumin+	4.20 ± 0.3	3.88 ± 0.38	3.61 ± 0.47	0.0001
CRP++	0.18 ± 0.24	0.51 ± 0.46	1.10 ± 1.23	0.0001
Homocysteine+++	11.19 ± 5.02	23.74 ± 5.33	24.00 ± 12.32	0.0001

Notes: CRP, C- reactive protein.

C/PD: *0.048; **0.017; ***0.044;+0.007; ++0.344; +++0.0001.

C/D: *0.018; **0.0001; ***0.013; +0.0001; ++0.0001; +++0.0001.

PD/D: *0.989; **0.0001; ***0.978; +0.01; ++0.016; +++0.992.

C, control group; PD, predialysis patient group; D, dialysis patient group.

*Insulin, **C-peptide, ***HOMA-IR.

+Albumin, ++CRP, +++Homocysteine.

Evaluation of the control, predialysis and dialysis patient groups with Tukey multiple comparison test p < 0.05.

Table 3. Evaluation of the existence of insulin resistance in the control, predialysis and dialysis groups.

Existence of insulin resistance	Control group	Predialysis patient group	Dialysis patient group
Insulin resistance (−)	100.00%	82.80%	80.60%	p = 0.026
Insulin resistance (+)	0.00%	17.20%	19.40%

Table 4. Correlation of C-peptide and HOMA-IR with insulin resistance.

Variables	Insulin resistance (−)	Insulin resistance (+)	Cut-off point	Sensitivity	Specificity
C-peptide	5.60 ± 3.47	10.52 ± 4.43	>3.53	100	75.00%
HOMA-IR	0.95 ± 0.56	5.21 ± 2.06	>1.56	98.9	95.83%