Renoprotection of Kolaviron against benzo (A) pyrene-induced renal toxicity in rats

Figures & data

Figure 1. Chemical structures of tested compounds. (A) Benzo[a]pyrene (B[a]P) and (B) Kolaviron (KV).

Figure 2. Plasma concentrations of urea (A) and creatinine (B) in experimental rats. KV1, 100 mg/kg Kolaviron; KV2, 200 mg/kg Kolaviron. Each bar represents mean ± SD of 10 rats per group after 15 d treatment period. a: p < 0.05 against control. b: p < 0.05 against B[a]P.

Figure 3. Effects of Kolaviron on circulatory levels of triiodothyronine (T₃), thyroxine (T₄) and T₃/T₄ ratio in B[a]P-treated rats. KV1, 100 mg/kg Kolaviron; KV2, 200 mg/kg Kolaviron. Each bar represents mean ± SD of 10 rats per group after 15 d treatment period. a: p < 0.05 against control. b: p < 0.05 against B[a]P.

Figure 4. Effect of Kolaviron on the activities of superoxide dismutase (SOD) and catalase (CAT) in kidneys of B[a]P-treated rats. KV1, 100 mg/kg Kolaviron; KV2, 200 mg/kg Kolaviron. Each bar represents mean ± SD of 10 rats per group after 15 d treatment period. a: p < 0.05 against control. b: p < 0.05 against B[a]P.

Figure 5. Effect of Kolaviron on glutathione (GSH) level and activities glutathione peroxidase (GPx) and glutathione S-transferase (GST) in kidneys of B[a]P-treated rats. KV1, 100 mg/kg Kolaviron; KV2, 200 mg/kg Kolaviron. Each bar represents mean ± SD of 10 rats per group after 15 d treatment period. a: p < 0.05 against control. b: p < 0.05 against B[a]P.

Figure 6. Effect of Kolaviron on MPO activity and levels of H₂O₂ and LPO in kidneys of B[a]P-treated rats. KV1, 100 mg/kg Kolaviron; KV2, 200 mg/kg Kolaviron. Each bar represents mean ± SD of 10 rats per group after 15 d treatment period. a: p < 0.05 against control. b: p < 0.05 against B[a]P.

Figure 7. Photomicrographs of kidneys from the experimental groups. The kidneys of control rats showing normal histology. The kidneys of B[a]P-treated rats showing some tubular lumen with numerous protein casts (arrow). The kidneys of rats co-treated with Kolaviron at 100 mg/kg (B[a]P + KV1) appear normal however with few protein casts in the lumen. The kidneys of rats co-treated with Kolaviron at 200 mg/kg (B[a]P + KV2) appeared structurally and functionally normal and comparable to control. Original magnification: × 240.