Comparison of serum cystatin C and creatinine levels in determining glomerular filtration rate in children with stage I to III chronic renal disease

Figures & data

Table 1. The correlation between creatinine and cystatin C and age, height, BMI in patient group.

C	Age	Height	BMI	Creatinine	Cystatin C
Creatinine	r = 0.425*	r = 0.383*	r = 0.143*	r = 1	r = 0.826*
	p < 0.001	p < 0.001	p < 0.00		p < 0.001
Cystatin C	r = 0.147	r = 0.101	r = 0.036	r = 0.826*	r = 1
	p = 0.058	p = 0.194	p = 0.648	p < 0.001*

Note: *p-Value < 0.05.

Table 2. The correlation between creatinine and cystatin C and age, height, BMI in control group.

	Age	Height	BMI	Creatinine	Cystatin C
Creatinine	r = 0.798*	r = 0.839*	r = 0.596*	r = 1	r = 0.153
	p < 0.001	p < 0.001	p = 0.001		p = 0.427
Cystatin C	r = –0.004	r = 0.025	r = 0.146	r = 0.153	r = 1
	p = 0.983	p = 0.898	p = 0.448	p = 0.427

Note: *p-Value < 0.05.

Table 3. GFR results in patients and controls.

	Patient		Control
	n	Mean ± SD	n	Mean ± SD
Creatinine clearance	166	107.5 ± 46.3	29	134.6 ± 28.2
Schwartz	166	121.5 ± 2.6	29	132.3 ± 2.6
Zapitelli 1	166	143.4 ± 7.1	29	149.5 ± 11.3
Zapitelli 2	166	117.7 ± 3.3	29	129.0 ± 5.0
p	<0.05		>0.05

Figure 1. ROC curve for cystatin C in detecting low GFR.

Figure 2. ROC curve for creatinine in detecting low GFR.

Figure 3. Bland–Altman analysis between Zappitelli 2 formula-based GFR and creatinine clearance.

Figure 4. Bland–Altman analysis between Zappitelli 1 formula-based GFR and creatinine clearance.

Figure 5. Bland–Altman analysis between schwartz formula-based GFR and creatinine clearance.