Thrombocytopenia as a predictor of severe acute kidney injury in patients with heat stroke

Figures & data

Table 1. Characteristics of patients by AKI status.

	AKI group (n = 103)	Non-AKI group (n = 73)	p Value
Age (year)	47.5 ± 28.3	39.6 ± 17.4	<0.01
Male (%)	77 (75%)	42 (57%)	0.27
Admission platelet counts (×10^9/L)	86.1 ± 21.4	145.6 ± 43.7	0.01
The nadir platelet counts (×10^9/L)	32.3 ± 19.0	79.6 ± 23.2	<0.01
Admission leukocyte counts (×10^9/L)	15.3 ± 6.2	12.3 ± 5.3	0.02
The peak leukocyte counts (×10^9/L)	19.4 ± 5.1	14.1 ± 3.4	0.01
Serum creatinine (µmol/L)	474.7 ± 201.8	87.2 ± 23.8	<0.01
Blood urea nitrogen (mmol/L)	34.2 ± 12.5	8.7 ± 5.8	<0.01
Hematuria (%)	79 (76.7%)	12 (16.4%)	<0.01
Proteinuria (%)	91 (88.3%)	15 (20.5%)	<0.01
Dialysis (%)	23 (22.3%)	0 (0%)	<0.01
Length of hospital stay (days)	29.4 ± 13.3	10.6 ± 4.3	0.01

Figure 1. Relationship between the nadir platelet counts and the peak blood creatinine (A), the peak blood urea nitrogen (B), and the lengths of hospital stay (C). The r denotes the Spearman correlation coefficient, and the line denotes the linear regression for each comparison.

Figure 2. ROC analysis of the platelet and leukocyte counts to predict AKI.

Table 2. The sensitivity and specificity were evaluated by the predictive values of AKI using different cut off values of platelet and leukocyte count (n = 103).

	Cut off values	Sensitivity	Specificity
Admission platelet counts (×10^9/L)	21	0.23	0.87
	42	0.91	0.51
	63	0.79	0.83
	84	0.86	0.59
The nadir platelet counts (×10^9/L)	10	0.31	0.97
	15	0.43	0.76
	30	0.90	0.81
	60	0.89	0.46
Admission leukocyte counts (×10^9/L)	15	0.63	0.79
The peak leukocyte counts (×10^9/L)	20	0.57	0.72

Table 3. Multiple logistic regression to identify hematological markers and other clinical indicators associated with the development of AKI (n = 103).

	Adjusted ORs	Adjusted 95% CI	p Value
Sex	0.83	0.21–4.72	0.57
Age (year)	1.06	0.94–1.10	0.09
Hematuria	6.79	1.93–29.36	<0.01
Proteinuria	2.87	0.34–10.76	0.31
Admission platelet counts (×10^9/L)	21.69	1.98–130.31	<0.01
The nadir platelet counts (×10^9/L)	37.92	2.18–87.21	<0.01
Admission leukocyte counts (×10^9/L)	1.07	0.13–3.49	0.61
The peak leukocyte counts (×10^9/L)	1.38	0.29–3.76	0.83

Notes: ORs: odds ratios; 95% CI: 95% confidence intervals; the nadir platelet counts: ≤ 30 × 10⁹/L; the peak leukocyte counts: ≥ 20 × 10⁹/L.