Do elevated plasma S100A12 levels predict atherosclerosis in peritoneal dialysis patients?

Figures & data

Table 1. Demographic characteristics and laboratory values of study population.

Variables	Patient group n = 56	Control group n = 20	p
Age (years)	48.1 ± 12.9	42.4 ± 6.9	0.063
Gender (n,%)
Male	25 (44.6%)	9 (45.0%)
Female	31 (55.4%)	11 (55.0%)	0.978
Smoking (%)	19.6	30	0.06
Blood pressure (mmHg)
Systolic	129.1 ± 20.3	116.1 ± 11.5	0.001
Diastolic	80.3 ± 11.3	74.7 ± 6.2	0.039
Mean arterial	96.5 ± 13.4	88.5 ± 7.5	0.002
BMI (kg/m^2)	25.4 ± 4.0	25.3 ± 3.7	0.912
CIMT(cm)	0.07 ± 0.02	0.06 ± 0.01	0.015
Blood urea nitrogen (mg/dL)	116.4 ± 29.0	24.9 ± 4.3	<0.001
Serum creatinine (mg/dL)	9.6 ± 1.9	0.8 ± 0.2	<0.001
Serum albumin (g/dL)	3.8 ± 0.4	4.4 ± 0.2	<0.001
C reactive protein (mg/dL)	1.6 ± 2.2	0.4 ± 0.3	<0.001
White blood cells/mm^3	7791.1 ± 2112.9	6945.0 ±1782.8	0.111
LDL-cholesterol (mg/dL)	110.9±36.0	114.5± 22.5	0.678
HDL-cholesterol (mg/dL)	40.1 ± 13.0	46.0 ± 9.0	0.034
Triglyceride (mg/dL)	176.8 ± 109.1	139.4 ± 93.3	0.177
S100A12 (ng/mL)	129.5 ± 167.2	48.5 ± 30.3	0.001

Notes: BMI, Body mass index; CIMT, carotid intima media thickness; LDL, low-density lipoprotein; HDL, high-density lipoprotein.

Bold values indicate p < 0.05.

Table 2. Demographic and laboratory values of patients according to the S100A12 groups.

Parameter	Group I (S100A2 ≤ 64.52)	Group II (S100A12 > 64.52)	p
Age (years)	46.4 ± 12.4	49.8 ± 13.4	>0.05
Dialysis vintage (months)	79.2 ± 41.1	61.08 ± 38.1	>0.05
SBP (mmHg)	130.5 ± 19.8	127.7 ± 21.1	>0.05
DBP (mmHg)	80.4 ± 11.3	80.2 ± 11.5	>0.05
MAP (mmHg)	97.1 ± 12.9	96 ± 14	>0.05
BMI (kg/m^2)	25.3 ± 4.2	25.5 ± 3.8	>0.05
CIMT (cm)	0.064 ± 0.019	0.073 ± 0.019	>0.05
Blood urea nitrogen (mg/dL)	113.3 ± 29.7	119.6 ± 28.5	>0.05
Serum creatinine (mg/dL)	9.6 ± 2.2	9.6 ± 1.6	>0.05
Ca (mg/dL)	9.24 ± 0.71	9.1 ± 0.34	>0.05
P (mg/dL)	4.89 ± 1.29	5.09 ± 1.41	>0.05
PTH	507.54 ± 382	447.76 ± 295.5	>0.05
ALP	130.61 ± 105.1	133.04 ± 81.46	>0.05
CRP	0.9 ± 0.9	2.3 ± 2.8	0.020
WBC cells/mm^3	6867.9 ± 1458.6	8714.3 ± 2280.1	0.001
LDL cholesterol (mg/dL)	105.1 ± 26.9	116.6 ± 43.1	>0.05
HDL cholesterol (mg/dL)	41.1 ± 14.3	39.2 ± 11.8	>0.05

Notes: SBP, Systolic blood pressure; DBP, diastolic blood pressure; MAP, mean arterial pressure; BMI, body mass index; CIMT, carotid intima media thickness; PTH, parathyroid hormone; CRP-C, reactive protein; LDL, low-density lipoprotein; HDL, high-density lipoprotein.

Bold values indicate p < 0.05.

Table 3. Patients according to the presence of RRF.

	RRF(−) (n = 38)	RRF(+) (n = 18)	p
Age (years)	47.84 ± 12.59	52.78 ± 12.6	0.304
MAP (mmHg)	95.18 ± 14.31	99.44 ± 10.86	0.250
Dialysis vintage (months)	74.6 ± 38.1	57.0 ± 40.2	0.520
Urea nitrogen (mg/dL)	112.2 ± 30.2	125.3 ± 24.8	0.106
BMI (kg/m^2)	24.5 ± 3.3	27.3 ± 4.6	0.03
Waist circumference (cm)	95.7 ± 6.4	102.4 ± 8.6	0.017
Serum creatinine (mg/dL)	10.0 ± 1.3	8.6 ± 2.3	0.020
Serum albumin (g/dL)	3.8 ± 0.4	3.7 ± 0.4	0.124
CRP (mg/dL)	1.3 ± 1.2	2.3 ± 3.3	0.284
WBC cells/mm^3	7694.8 ± 2056.4	7994.4 ± 2275.0	0.916
LDL-cholesterol (mg/dL)	110.7 ± 34.6	111.3 ± 39.9	0.909
HDL cholesterol (mg/dL)	40.0 ± 13.2	40.3 ± 13.1	0.928
CIMT (cm)	0.07 ± 0.02	0.07 ± 0.02	0.781
S100A12 (ng/mL)	129.4 ± 180.3	129.2 ± 140.7	0.522

Bold values indicate p < 0.05.

Table 4. Carotid intima media thickness correlations.

Parameters	CIMT correlation (N = 56)	p
Age	0.354	0.007
Dialysis vintage	−0.153	0.259
MAP	0.213	0.114
BMI	0.204	0.131
RRV	0.079	0.561
Kt/V	0.094	0.489
S100A12	0.293	0.028
Urea nitrogen	−0.062	0.649
Creatinine	−0.225	0.095
Albumin	−0.090	0.551
CRP	0.269	0.045
ALP	−0.057	0.674
Ca	0.091	0.505
P	0.208	0.123
PTH	−0.162	0.232
WBC	0.106	0.438
Total-cholesterol	0.028	0.839
LDL-cholesterol	0.066	0.628
HDL-cholesterol	0.30	0.827
Triglycerides	−0.062	0.649
Hgb	−0.264	0.049

Notes: MAP, Mean arterial pressure; BMI, body mass index; RRF, residual renal function; CIMT, carotid intima media thickness; PTH, parathyroid hormone; CRP-C, reactive protein; LDL, low-density lipoprotein; HDL, high-density lipoprotein.

Bold values indicate p < 0.05.

Table 5. Regression analysis.

Model	B	Std.Error	Beta	t	Sig.
	0.071	0.015		4.768	0.000
Hgb	−0.006	0.000	−0.080	−0.517	0.607
Age	0.000	0.000	0.308	2.446	0.018
S100A12	0.002	0.001	0.248	2.013	0.049
CRP	0.001	0.001	0.164	1.082	0.284

Bold values indicate p < 0.05.