Effect of donor age and parent-to-child transplant on living-related donor kidney transplantation: a single center's experience of 236 cases

Figures & data

Table 1. Baseline characteristics of kidney recipients and donors (n = 236) in the renal transplantation study (frequency for categorical variables, mean ± SD for continuous variables).

	Recipients	Donors
Male (%)	186 (78.8)	112 (47.5)
Age, yrs (range)	32.1 ± 9.4 (6–65)	44.1 ± 11.5 (19–66)
Weight, kg (range)	56.8 ± 10.3 (15–84)	58.1 ± 9.1 (40–90)
Pre-transplant Cr, μmol/L (range)	1046.9 ± 384.6 (45–2077)	66.9 ± 15.9 (36–132)
Donor–recipient gender combination (%)
Male–male	90 (38.1)
Male–female	22 (9.3)
Female–male	96 (40.7)
Female–female	28 (11.9)
Donor–recipient relationship (%)
Parent–child	113 (47.9)
Child–parent	5 (2.1)
Sibling	66 (30.0)
Other collateral relatives	44 (18.6)
Spouse	7 (3.0)
Others	1 (0.4)

Table 2. Baseline characteristics of recipients and donors by donor–recipient relationship groups (parent–child vs. others).

	Parent–child (n = 113)	Others (n = 123)
Recipients
Male (%)	89 (78.8)	97 (78.9)
Age, yrs (range)	28.8 ± 7.1 (6–49)	35.3 ± 10.2 (6–65)*
Weight, kg (range)	55.7 ± 9.9 (15–75)	57.7 ± 10.5 (16–84)
Pre-transplant Cr, μmol/L (range)	1094.0 ± 384.6 (193–2059)	1003.0 ± 381.0 (45–2077)
Donors
Male (%)	50 (44.3)	62 (50.4)
Age, yrs (range)	52.3 ± 7.3 (23–66)	36.6 ± 9.3 (19–62)*
Weight, kg (range)	58.3 ± 8.4 (40–90)	57.9 ± 9.7 (40–80)
Pre-transplant Cr, μmol/L (range)	65.8 ± 14.4 (39–110)	67.9 ± 17.1 (36–132)
Donor–recipient gender combination (%)
Female–male	48 (42.5)	48 (39.0)
Others	65 (57.5)	75 (61.0)

Note: *p < 0.05 between the two groups.

Table 3. Baseline characteristics of recipients and donors by donor age groups (<50 years vs. ≥ 50 years).

	Donor age < 50 yrs (n = 146)	Donor age ≥ 50 yrs (n = 90)
Recipients
Male (%)	115 (78.8%)	71 (78.9%)
Age, yrs (range)	33.2 ± 10.1 (6–65)	30.4 ± 7.9 (6–65)
Weight, kg (range)	56.7 ± 10.2 (16–84)	56.9 ± 10.4 (15–76)
Pre-transplant Cr, μmol/L (range)	1027.1 ± 378.3 (45–2077)	1078.0 ± 394.5 (193–1966)
Donors
Male (%)	65 (44.5%)	47 (52.2%)
Age, yrs (range)	36.7 ± 8.0 (19–49)	55.8 ± 3.9 (50–66)*
Weight, kg (range)	57.8 ± 9.3 (40–88)	58.6 ± 8.8 (44–90)
Pre-transplant Cr, μmol/L (range)	66.8 ± 17.0 (36–132)	67.0 ± 14.0 (40–110)
Donor–recipient gender combination (%)
Female–male	62 (42.5%)	34 (37.8%)
Others	84 (57.5%)	56 (62.2%)
Donor–recipient relationship (%)
Parent–child	34 (23.3%)	79 (87.8%)*
Others	112 (76.7%)	11 (12.2%)*

Note: *p < 0.05 between the two groups.

Table 4. Adjusted mean differences (SE) of post-transplant creatinine levels in recipients between parent-to-child transplants versus others, and between older (≥50 years) versus younger (<50 years) donors.

	Parent-to-child versus others	Donor age ≥ 50 years versus < 50 years
Time-points post-transplant
1 month	3.86 (5.53)	10.83 (5.76)
6 months	10.42 (5.11)*	16.96 (5.38)**
1 year	6.78 (5.53)	11.40 (5.65)*
3 years	23.69 (9.23)*	25.39 (10.40)*
5 years	2.30 (15.80)	3.22 (13.92)
Covariate
Donor age, yrs	0.76 (0.18)**	–
Recipient age, yrs	−0.03 (0.23)	−0.05 (0.24)
Donor gender, male	11.39 (10.51)	11.07 (10.24)
Recipient gender, male	7.35 (8.06)	8.27 (7.76)
Donor pre-transplant Cr, μmol/L	0.31 (0.15)*	0.32 (0.14)*
Recipient pre-transplant Cr, μmol/L	0.01 (0.005)*	0.01 (0.005)
Female-to-male	20.27 (10.77)	20.04 (10.52)
Parent-to-child	–	11.87 (4.98)*

Notes: Results for covariate are estimated regression coefficients (SE).

*p < 0.05.

**p < 0.01.

Table 5. Adjusted rood ratio with 95% CI for parent-to-child transplant and older donor with high recipient creatinine levels (>115 μmol/L) at post-transplant time points.

1 Month post-transplant
Parent-to-child, donor age ≥ 50 yrs	3.49 (1.72–7.06)**
Other relationship, donor age ≥ 50 yrs	2.13 (0.49–9.33)
Parent-to-child, donor age < 50 yrs	2.49 (0.97–6.39)
Other relationship, donor age < 50 yrs	1
6 Months post-transplant
Parent-to-child, donor age ≥ 50 yrs	7.89 (3.71–16.77)**
Other relationship, donor age ≥ 50 yrs	4.78 (1.02–22.49)*
Parent-to-child, donor age < 50 yrs	2.96 (1.14–7.64)*
Other relationship, donor age <50 yrs	1
1 Year post-transplant
Parent-to-child, donor age ≥ 50 yrs	4.48 (2.20–9.11)**
Other relationship, donor age ≥ 50 yrs	10.43 (2.01–54.20)**
Parent-to-child, donor age < 50 yrs	2.24 (0.90–5.58)
Other relationship, donor age < 50 yrs	1
3 Years post-transplant
Parent-to-child, donor age ≥ 50 yrs	8.07 (3.15–20.63)**
Other relationship, donor age ≥ 50 yrs	9.70 (1.79–52.55)**
Parent-to-child, donor age < 50 yrs	4.70 (1.49–14.83)**
Other relationship, donor age < 50 yrs	1

Notes: Comparison with other donor–recipient relationships and donor age <50 years; adjusted for recipient age, donor and recipient gender, and pre-transplant creatinine levels.

*p < 0.05.

**p < 0.01.