Single nucleotide polymorphisms near IL28B gene and response to treatment of chronic hepatitis C in hemodialysis patients

Figures & data

Table 1. The demographic data and etiology of renal disease of the hemodialysis patients.

Hemodialysis patients, No	24
Gender, No (%)
Men	22 (91.7%)
Women	2 (8.3%)
Age, years, (mean ± SD)	47.8 ± 11.6
HD duration, months, (mean ± SD)	152.5 ± 59.9
Etiology of renal disease, No (%)
Glomerulonephropathy	10 (41.7%)
Polycystic kidney	4 (16.7%)
Interstitial nephropathy	3 (12.5%)
Nephroarteriolosclerosis	3 (12.5%)
Other nephropathy	4 (16.6%)

Figure 1. Distribution of the frequencies of rs12979860 (a), rs8099917 (b), and rs12980275 (c) genotypes in the study participants.

Table 2. Sustained virological response and the SNPs near IL28B gene in HD patients.

HD† patients	rs12979860	CC	non CC (CT,TT)	p
SVR*, No (%)		11 (91.7%)	1 (8.3%)
Non SVR**, No (%)		3 (25.0%)	9 (75.0%)	0.003
	rs8099917	TT	non TT (TG,GG)	p
SVR*, No (%)		11 (91.7%)	1 (8.3%)
Non SVR**, No (%)		4 (33.3%)	8 (62.7%)	0.009
	rs 12980275	AA	non AA (AG,GG)	p
SVR*, No (%)		10 (83.3%)	2 (16.7%)
Non SVR**, No (%)		3 (25.0%)	9 (75.0%)	0.012

Notes: †Hemodialysis.

*Achieved sustained virological response.

**No achievement of sustained virological response.